Your session is about to expire
← Back to Search
Other
Angiotensin 1-7 for Heart Failure
Phase 1 & 2
Waitlist Available
Led By Lee Ryan, Ph.D.
Research Sponsored by University of Arizona
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up these measurements will be taken at the 12 month follow up
Awards & highlights
Study Summary
This trial is testing whether a drug called Ang-(1-7) can prevent cognitive impairment in people with heart failure who are at risk for developing VCID/ADRD. The trial will last for one year, and participants will have to undergo neuropsychological testing and blood draws at baseline and at the 12-month mark. They will also be given weekly check-ins during the 12-week treatment period.
Eligible Conditions
- Heart Failure
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ these measurements will be taken at the 12 month follow up
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~these measurements will be taken at the 12 month follow up
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
12-month Blood Biomarkers - Neurology 4-Pleax A, pTau-181, and pTau 231 as measured by the Quanterix Simoa Neurology 4-plex A and Simoa pTau-181 and 283 advantage kits
12-month evaluations of associative, verbal memory as measured by the verbal paired associates task (version 2)
12-month evaluations of associative, visual memory as measured by the Face Name Associative Memory Test
+33 moreTrial Design
2Treatment groups
Experimental Treatment
Placebo Group
Group I: Ang-(1-7)Experimental Treatment1 Intervention
30 participants will take 100 micrograms of Ang-(1-7) a day via subcutaneous injection for 90 days
Group II: Saline PlaceboPlacebo Group1 Intervention
10 participants will take 100 micrograms of saline placebo a day via subcutaneous injection for 90 days
Find a Location
Who is running the clinical trial?
University of ArizonaLead Sponsor
514 Previous Clinical Trials
148,231 Total Patients Enrolled
2 Trials studying Heart Failure
56 Patients Enrolled for Heart Failure
Lee Ryan, Ph.D.Principal InvestigatorUniversity of Arizona
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- You currently use drugs or have a history of using certain drugs like cocaine, ecstasy, LSD, or injecting drugs.Your systolic blood pressure is less than 95 mmHg.You have signs of severe heart failure that is not well controlled.You are showing symptoms or signs of a current heart problem.You have serious lung disease with specific measurements of lung function and blood gases.You have a history of seizures or are currently taking medication for seizures, except for seizures that occurred during childhood due to fever.You have a medical condition that affects how your brain works, like a stroke, head injury, Alzheimer's, Parkinson's, or brain cancer.You are currently experiencing severe depression.You must be at least 45 years old.You have been diagnosed with heart failure at least 90 days before joining the study and have symptoms like shortness of breath during mild or moderate exercise, but not at rest.
Research Study Groups:
This trial has the following groups:- Group 1: Ang-(1-7)
- Group 2: Saline Placebo
Awards:
This trial has 0 awards, including:Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Is this experiment gathering new participants?
"Information from clinicaltrials.gov states that this trial, first posted on April 1st 2022, is no longer recruiting patients into the study. However, at present there are 700 alternative trials actively seeking participants."
Answered by AI
Other Trials to Consider
Popular Categories
Share this study with friends
Copy Link
Messenger