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Polycyclic Aromatic Hydrocarbon

[14C]-benzo[a]pyrene for Environmental Exposures

Phase < 1
Waitlist Available
Research Sponsored by Oregon State University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 48 hours
Awards & highlights

Study Summary

This trial is evaluating how the body processes a small amount of a chemical called benzo[a]pyrene, given four times at different doses.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~48 hours
This trial's timeline: 3 weeks for screening, Varies for treatment, and 48 hours for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Plasma and urine benzo[a]pyrene and metabolite levels after oral dose
Secondary outcome measures
Area under plasma concentration versus time curve AUC
Metabolites in plasma
Metabolites in urine
+3 more

Trial Design

4Treatment groups
Experimental Treatment
Group I: 50 ng doseExperimental Treatment1 Intervention
Capsule containing 50 ng (2.7 nCi) [14C]-benzo[a]pyrene (BaP)
Group II: 250 ng doseExperimental Treatment1 Intervention
Capsule containing 100 ng (2.7 nCi) [14C]-benzo[a]pyrene (BaP)
Group III: 25 ng doseExperimental Treatment1 Intervention
Capsule containing 25 ng (2.7 nCi) [14C]-benzo[a]pyrene (BaP)
Group IV: 100 ng doseExperimental Treatment1 Intervention
Capsule containing 100 ng (2.7 nCi) [14C]-benzo[a]pyrene (BaP)
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
[14C]-benzo[a]pyrene
2018
Completed Early Phase 1
~20

Find a Location

Who is running the clinical trial?

Oregon State UniversityLead Sponsor
49 Previous Clinical Trials
8,373 Total Patients Enrolled
3 Trials studying Environmental Exposures
452 Patients Enrolled for Environmental Exposures
National Institute of Environmental Health Sciences (NIEHS)NIH
284 Previous Clinical Trials
1,232,729 Total Patients Enrolled
12 Trials studying Environmental Exposures
4,758 Patients Enrolled for Environmental Exposures
Pacific Northwest National LaboratoryFED
9 Previous Clinical Trials
3,768 Total Patients Enrolled
2 Trials studying Environmental Exposures
12 Patients Enrolled for Environmental Exposures

Media Library

Benzo[a]Pyrene (Polycyclic Aromatic Hydrocarbon) Clinical Trial Eligibility Overview. Trial Name: NCT03318978 — Phase < 1
Environmental Exposures Research Study Groups: 100 ng dose, 25 ng dose, 250 ng dose, 50 ng dose
Environmental Exposures Clinical Trial 2023: Benzo[a]Pyrene Highlights & Side Effects. Trial Name: NCT03318978 — Phase < 1
Benzo[a]Pyrene (Polycyclic Aromatic Hydrocarbon) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03318978 — Phase < 1

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is enrollment available for individuals who are of age twenty or over in this trial?

"The parameters for inclusion in this study necessitate that all participants are between 21 and 65 years old. There exists 6 trials specifically designed for those beneath the age of majority, as well 12 research studies focused on individuals above retirement age."

Answered by AI

Is this research endeavor actively recruiting participants?

"Unfortunately, according to clinicaltrials.gov this investigation is no longer recruiting patients after being initially posted on April 17th 2018 and last updated on October 17 2022. Fortunately though, there are presently 15 other medical studies actively seeking participants."

Answered by AI

Am I eligible to participate in this clinical research?

"This clinical trial seeks 8 volunteers between the ages of 21 and 65 who have experienced environmental exposures. To be considered, participants must meet additional requirements such as being post-menopausal or having undergone a surgical sterilization procedure. Other dietary restrictions include avoiding cruciferous vegetables, I3C or DIM supplements, smoked or cured meats/cheeses, and charcoal-grilled foods for two weeks prior to and during each study cycle (gas grilled food is permissible). Additionally, those enrolled in this medical research must refrain from donating blood one month before starting their involvement with the study activities until one month after it concludes."

Answered by AI
~1 spots leftby Apr 2025