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Fluoroquinolone Antibiotic

Zimoxin for Cataract Surgery Prevention

Phase 2 & 3

Waitlist Available

Research Sponsored by Jason Ahee, M.D.

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

visually significant cataracts

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up subjects will undergo eye examinations at one day, one week, and one month post-operatively

Awards & highlights

Study Summary

This trial is testing whether or not a certain eye drop can help prevent infection after surgery.

Who is the study for?

This trial is for individuals with visually significant cataracts who are undergoing surgery. It's not suitable for those allergic to fluoroquinolones or cobalamin (B12).Check my eligibility

What is being tested?

The study tests the safety and effectiveness of an eye injection called Zimoxin, which contains moxifloxacin, to prevent infection after cataract surgery compared to a placebo.See study design

What are the potential side effects?

Possible side effects may include irritation in the eye, redness, swelling, or other signs of infection due to the moxifloxacin solution.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I have cataracts that affect my vision significantly.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ subjects will undergo eye examinations at one day, one week, and one month post-operatively

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~subjects will undergo eye examinations at one day, one week, and one month post-operatively

This trial's timeline: 3 weeks for screening, Varies for treatment, and subjects will undergo eye examinations at one day, one week, and one month post-operatively for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Endophthalmitis after cataract surgery

Trial Design

2Treatment groups

Active Control

Placebo Group

Group I: Treatment groupActive Control1 Intervention

Intracameral injection of moxifloxacin solution after cataract surgery

Group II: Placebo groupPlacebo Group1 Intervention

Intracameral injection of placebo after cataract surgery

0 / 1Eligibility criteria met

Find a Location

Who is running the clinical trial?

Jason Ahee, M.D.Lead Sponsor

Media Library

Moxifloxacin (Fluoroquinolone Antibiotic) Clinical Trial Eligibility Overview. Trial Name: NCT03244072 — Phase 2 & 3

Endophthalmitis Clinical Trial 2023: Moxifloxacin Highlights & Side Effects. Trial Name: NCT03244072 — Phase 2 & 3

Moxifloxacin (Fluoroquinolone Antibiotic) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03244072 — Phase 2 & 3

Endophthalmitis Research Study Groups: Treatment group, Placebo group

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the general conditions that Treatment group is meant to address?

"The treatment group is most often used to deal with bacterial conjunctivitis. Other eye conditions it can be effective against include ocular bacterial infections, plague, and postoperative infections."

Answered by AI

Are there any available positions for patients who want to participate in this trial?

"As of 8/22/2022, this particular clinical trial is no longer actively recruiting patients. The study was originally posted on 1/1/2023 and has not seen any updates in over 6 months. There are currently 145 trials related to endophthalmitis enrolling patients and 26 studies for the Treatment group that have active recruitment postings."

Answered by AI

Are the results of this study unique to Treatment group, or have other research teams observed similar effects?

"At this moment, 26 different clinical trials are researching the efficacy of Treatment group. Of these, 13 have progressed to Phase 3 testing. Many of the ongoing studies for Treatment group are based out of Redwood City in California; however, there are 488 total research sites across the globe."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Safety and Efficacy of Intracameral Zimoxin for Prevention of Endophthalmitis After Cataract Surgery

Jason Ahee, M.D. 2024. "Safety and Efficacy of Intracameral Zimoxin for Prevention of Endophthalmitis After Cataract Surgery". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03244072.

All > Cataract