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Antidepressant

Bupropion XL for Depression

Phase 4
Waitlist Available
Led By Andrew Miller, MD
Research Sponsored by Emory University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, week 2, week 4, week 6, week 8
Awards & highlights

Study Summary

This trial will test whether bupropion can help people with depression and increased inflammation who also have problems with anhedonia.

Eligible Conditions
  • Depression

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, week 2, week 4, week 6, week 8
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, week 2, week 4, week 6, week 8 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in Targeted Ventromedial Prefrontal Cortex-Ventral Striatal (vmPFC-VS) Functional Connectivity (FC)
Secondary outcome measures
Inventory of Depressive Symptomatology - Self-Report (IDS-SR)
Motivation and Pleasure Scale-Self-Report (MAP-SR) Score
Proportion of Hard-Task Choices During the Effort-Expenditure for Rewards Task (EEfRT)
+1 more

Side effects data

From 2022 Phase 4 trial • 18 Patients • NCT04352101
20%
Itching
20%
Nausea
20%
Anxious mood
10%
Insomnia
10%
Dry mouth
10%
Vivid dreams
10%
Pain in limb
10%
Nocturnal perspiration
10%
Lightheadedness
10%
Headache
10%
Stress
10%
Chest pain
10%
High blood pressure
10%
Enlarged lymph nodes
100%
80%
60%
40%
20%
0%
Study treatment Arm
Bupropion
Escitalopram

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: BupropionExperimental Treatment1 Intervention
Participants randomized to take bupropion for 8 weeks.
Group II: EscitalopramActive Control1 Intervention
Participants randomized to take escitalopram for 8 weeks.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Bupropion XL
2009
Completed Phase 4
~370

Find a Location

Who is running the clinical trial?

Emory UniversityLead Sponsor
1,636 Previous Clinical Trials
2,560,555 Total Patients Enrolled
59 Trials studying Depression
8,998 Patients Enrolled for Depression
National Institute of Mental Health (NIMH)NIH
2,782 Previous Clinical Trials
2,689,089 Total Patients Enrolled
665 Trials studying Depression
251,416 Patients Enrolled for Depression
Andrew Miller, MDPrincipal InvestigatorEmory University
2 Previous Clinical Trials
374 Total Patients Enrolled
1 Trials studying Depression
20 Patients Enrolled for Depression

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the maximum intake for participants in this research project?

"Affirmative, the clinical trial is presently enrolling patients. It was initially listed on September 23rd 2020 and had its most recent update on December 21st 2021. 50 participants are required from a single site for this study to be successful."

Answered by AI

Is this research initiative open to individuals aged 55 and over?

"This medical study is looking to enrol patients between the ages of 25 and 55. Those younger than 18 are eligible for 186 other trials, whereas 978 studies exist for those over 65 years old."

Answered by AI

Under what medical circumstances is Bupropion XL commonly administered?

"Bupropion XL is frequently prescribed to treat obsessive-compulsive disorder, but can also assist individuals with ADHD, seasonal affective disorder and smoking cessation."

Answered by AI

Does this medical investigation offer volunteer opportunities at the present time?

"Evidenced by clinicaltrials.gov, this study is on the search for participants. It was first advertised in September 23rd 2020 and its latest update took place on December 21st 2021."

Answered by AI

To what extent have other experiments been conducted utilizing Bupropion XL?

"As of now, 51 live studies examining Bupropion XL are ongoing with 14 in the third stage. The majority of these trials are held in Bridgewater, New jersey, but there is a total 323 locations hosting research on this medication."

Answered by AI

To which demographic is enrollment in this research endeavor accessible?

"This clinical trial is recruiting 50 volunteers between the ages of 25 and 55 who have been diagnosed with depression. Applicants must not be taking any antidepressants or other psychotropic medicines, such as mood stabilisers, antipsychotics, or sedative hypnotics for a minimum 4 weeks prior to the baseline visit (8 weeks if they were prescribed fluoxetine). Clonazepam may be administered at up to 2mg per day but no assessments can take place within 12 hours of intake. Furthermore, participants should have an IDS-SR Anhedonia subscale score ≥ 5 and 16-item Quick Inventory of Depressive Sympt"

Answered by AI

Does the FDA recognize Bupropion XL as a viable medication?

"There is already approval for the use of Bupropion XL, so it's safety rating has been assigned a 3 on our scale."

Answered by AI

Who else is applying?

What state do they live in?
Georgia
What site did they apply to?
Emory Clinic
What portion of applicants met pre-screening criteria?
Did not meet criteria
How many prior treatments have patients received?
1

Why did patients apply to this trial?

I am interested in this clinical trial because I need help with controlling my depression. I haven’t been on any depression meds in years, but I have been struggling severely with it this past year. I could also use the extra money from paid clinical trial and get help without the expense of dr. Appt and prescriptions.
PatientReceived no prior treatments

What questions have other patients asked about this trial?

How often will I need to report?
PatientReceived no prior treatments
Recent research and studies
clinicaltrials.govStudy
Bupropion Versus Escitalopram on Reward Circuitry and Motivational Deficits
Andrew H Miller 2020. "Bupropion Versus Escitalopram on Reward Circuitry and Motivational Deficits". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04352101.
~4 spots leftby Apr 2025
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