72 Participants Needed

MK-6194 for Atopic Dermatitis

Recruiting at 19 trial locations
TF
Overseen ByToll Free Number
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial is testing a new treatment called MK-6194 to see if it is safe and tolerable for people with moderate to severe atopic dermatitis who haven't had success with other treatments.

Do I need to stop my current medications to join the trial?

The trial information does not specify if you need to stop taking your current medications. However, it mentions that participants should not be on chronic systemic anti-infective therapy for certain infections. It's best to discuss your specific medications with the trial team.

Who Is on the Research Team?

MD

Medical Director

Principal Investigator

Merck Sharp & Dohme LLC

Are You a Good Fit for This Trial?

This trial is for adults with moderate to severe atopic dermatitis (eczema) who haven't improved with standard treatments. They must have a stable weight (BMI between 18 and 38), been diagnosed with eczema for at least 6 months, and not responded well to strong skin creams or ointments recently.

Inclusion Criteria

My skin condition is moderate to severe.
My skin condition didn't improve after using strong skin creams for over a month.
Your body mass index (BMI) should be between 18 and 38.
See 1 more

Exclusion Criteria

I haven't had serious heart issues, stroke, or uncontrolled diabetes or blood pressure in the last 6 months.
I have had a severe shingles outbreak or a widespread herpes infection recently.
I am on long-term medication for a chronic infection.
See 6 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive multiple rising doses of MK-6194 or placebo every 2 weeks

12 weeks
6 visits (in-person)

Follow-up

Participants are monitored for safety and effectiveness after treatment

12 weeks
3 visits (in-person)

What Are the Treatments Tested in This Trial?

Interventions

  • MK-6194
Trial Overview The study tests MK-6194's safety and how well it's tolerated when given multiple times to people with tough-to-treat eczema. Some participants will receive MK-6194, while others will get a placebo, which has no active drug in it.
How Is the Trial Designed?
6Treatment groups
Experimental Treatment
Group I: Expansion Panel EExperimental Treatment2 Interventions
Participants are randomized to a dose less than or equal to high dose MK-6194 or placebo administered q2w.
Group II: Expansion Panel DExperimental Treatment2 Interventions
Participants are randomized to medium dose MK-6194 or placebo administered q2w.
Group III: Expansion Dose FExperimental Treatment2 Interventions
Participants are randomized to a dose less than or equal to high dose MK-6194 or placebo q2w.
Group IV: Dose Escalation Panel CExperimental Treatment2 Interventions
Participants are randomized to high dose MK-6194 or placebo administered q2w.
Group V: Dose Escalation Panel BExperimental Treatment2 Interventions
Participants are randomized to medium dose MK-6194 or placebo administered q2w.
Group VI: Dose Escalation Panel AExperimental Treatment2 Interventions
Participants are randomized to low dose MK-6194 or placebo, administered every 2 weeks (q2w).

Find a Clinic Near You

Who Is Running the Clinical Trial?

Merck Sharp & Dohme LLC

Lead Sponsor

Trials
4,096
Recruited
5,232,000+
Chirfi Guindo profile image

Chirfi Guindo

Merck Sharp & Dohme LLC

Chief Marketing Officer since 2022

Degree in Engineering from Ecole Centrale de Paris, MBA from New York University Stern School of Business

Robert M. Davis profile image

Robert M. Davis

Merck Sharp & Dohme LLC

Chief Executive Officer since 2021

JD from Northwestern University Pritzker School of Law, MBA from Northwestern University Kellogg Graduate School of Management, Bachelor's in Finance from Miami University

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