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Procedure
Endoscopic Surgery Techniques for Pancreatitis (DESTIN Trial)
N/A
Waitlist Available
Led By Ji Young Bang, MD MPH
Research Sponsored by Orlando Health, Inc.
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6 months
Awards & highlights
DESTIN Trial Summary
This trial is comparing two different ways to do surgery on the pancreas for people with a certain kind of pancreatitis.
Who is the study for?
This trial is for adults over 18 with necrotizing pancreatitis, who have a symptomatic necrotic collection visible on MRI or CT scans and suitable for drainage guided by endoscopic ultrasound (EUS). It's not for those under 18, pregnant women, patients with severe clotting issues, those on certain anticoagulants that can't be stopped, or if consent cannot be obtained.Check my eligibility
What is being tested?
The study compares two approaches to treating necrotizing pancreatitis: immediate removal of dead tissue through an endoscope versus a gradual treatment approach starting with less invasive procedures. Patients are randomly assigned to one of these treatments.See study design
What are the potential side effects?
Potential side effects may include bleeding, infection at the site of intervention, pain related to the procedure(s), possible damage to surrounding organs during the procedure and reactions related to sedation.
DESTIN Trial Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 6 months
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6 months
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Total number of reinterventions required for treatment success
Secondary outcome measures
Overall treatment costs measured in US dollars
Post-procedure length of intensive care unit (ICU) stay
Rate of disease-related adverse events
+10 moreDESTIN Trial Design
2Treatment groups
Active Control
Group I: Step-up endoscopic interventionActive Control1 Intervention
Endoscopic ultrasound (EUS)-guided drainage of the necrotic collection is performed using a lumen-apposing metal stent. In this group, only EUS-guided drainage of the necrotic collection will be performed, and endoscopic necrosectomy will be performed at a separate session at a later time as needed.
Group II: Immediate endoscopic necrosectomyActive Control1 Intervention
Endoscopic ultrasound (EUS)-guided drainage of the necrotic collection is performed using a lumen-apposing metal stent. Then in this group, endoscopic necrosectomy will be performed immediately following index EUS-guided drainage of the necrotic collection, during the same session
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Who is running the clinical trial?
University of Southern CaliforniaOTHER
905 Previous Clinical Trials
1,596,208 Total Patients Enrolled
Marshall UniversityOTHER
20 Previous Clinical Trials
4,092 Total Patients Enrolled
Mayo ClinicOTHER
3,206 Previous Clinical Trials
3,767,013 Total Patients Enrolled
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- You have a collection of dead tissue that cannot be drained with ultrasound guidance.
Research Study Groups:
This trial has the following groups:- Group 1: Step-up endoscopic intervention
- Group 2: Immediate endoscopic necrosectomy
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
What is the current enrollment count for this experiment?
"Affirmative. According to clinicaltrials.gov, recruitment is currently in progress for this medical experiment; it was officially posted on August 18th 2021 and the last update occurred October 4th 2022. 70 people are necessary from a single site to complete this trial's requirements."
Answered by AI
Is this research endeavor presently looking for new participants?
"The information on clinicaltrials.gov reveals that this research project is still recruiting participants. It was first posted in August 18th 2021 and underwent its last edit October 4th 2022."
Answered by AI
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