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Behavioral Intervention

Diagnostic Tests Reliability for Pain Perception

N/A

Recruiting

Led By Benedict Alter, MD, PhD

Research Sponsored by University of Pittsburgh

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be between 18 and 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline

Awards & highlights

Study Summary

This trial is measuring how well two tests (OA and OH) work to show how the brain changes pain. These tests use a heat thermode to cause pain in healthy volunteers, and then additional surveys about pain will be collected. If these tests work well, they could be used to help develop new pain medications and to help choose treatments that would work best for each person.

Who is the study for?

This trial is for healthy, pain-free volunteers who have no chronic pain issues and can understand the study procedures. It's not suitable for those with a history of chronic pain, significant ongoing acute or chronic pain, recent migraines, mood disorders, taking certain medications affecting the nervous system, cognitive impairments, unstable medical conditions, pregnancy, forearm tattoos, heart or severe liver/gastrointestinal diseases.Check my eligibility

What is being tested?

The study aims to test the reliability of offset analgesia (OA) and onset hyperalgesia (OH), which are methods used to measure how our brain controls pain. Participants will undergo heat-induced OA and OH tests across three visits along with other quantitative sensory testing and surveys related to pain modulation.See study design

What are the potential side effects?

Since this trial involves non-invasive sensory testing primarily using a heat thermode on healthy individuals without any medication administration involved in the interventions being tested (Medoc cutaneous probe), side effects are expected to be minimal but may include temporary discomfort from heat exposure.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 4 weeks after baseline

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~4 weeks after baseline

This trial's timeline: 3 weeks for screening, Varies for treatment, and 4 weeks after baseline for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Differences in brain region activation- QST (quantitative sensory tests)

Offset analgesia and onset hyperalgesia

Test retest reliability in brain region activation- QST (quantitative sensory tests)

+1 more

Secondary outcome measures

Differences in resting fNIRS signaling

Pain intensity

Questionnaire score- Beck Depression Inventory-II (BDI-II)

+7 more

Trial Design

1Treatment groups

Experimental Treatment

Group I: Healthy VolunteersExperimental Treatment3 Interventions

QST devices and computer tasks are used to measure OA, OH, pain intensity, and other outcomes

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Quantitative sensory testing

2016

Completed Phase 4

~630

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

University of PittsburghLead Sponsor

1,722 Previous Clinical Trials

16,342,856 Total Patients Enrolled

17 Trials studying Pain

8,581 Patients Enrolled for Pain

Benedict Alter, MD, PhDPrincipal InvestigatorUniversity of Pittsburgh

1 Previous Clinical Trials

110 Total Patients Enrolled

Media Library

Computer tasks (Behavioral Intervention) Clinical Trial Eligibility Overview. Trial Name: NCT05487183 — N/A

Pain Research Study Groups: Healthy Volunteers

Pain Clinical Trial 2023: Computer tasks Highlights & Side Effects. Trial Name: NCT05487183 — N/A

Computer tasks (Behavioral Intervention) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05487183 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are applicants above the age of fifty precluded from participating in this experiment?

"In order to enroll in this medical trial, applicants must be between 18 and 50. Conversely, there are 82 trials available for minors and 328 specifically tailored towards seniors."

Answered by AI

Is there still the possibility for individuals to participate in this medical trial?

"According to clinicaltrials.gov, the recruitment process for this medical trial is ongoing since its initial posting on August 5th 2022 and last update on September 9th 2022."

Answered by AI

Who is eligible to volunteer for this investigation?

"This investigation requires 90 adults aged between 18 and 50 who have experienced pain to join. Furthermore, it is mandatory that they must be healthy volunteers without any prolonged aches or capable of comprehending the procedures associated with this trial."

Answered by AI

What is the uppermost capacity of participants in this research project?

"Indeed, clinicaltrials.gov has information indicating that this medical trial is presently enrolling patients. It was first posted on August 5th 2022 and last refreshed on September 9th 2022. The study seeks to recruit 90 individuals from a single site of research."

Answered by AI

What is the overarching goal of this experiment?

"The primary assessment for this trial, which will take place over a period of 4 weeks from the baseline measurement, is to ascertain the offset analgesia and onset hyperalgesia's test-retest reliability. Secondary parameters encompass pain intensity (scaled 0-100 with 100 representing maximum agony), Beck Depression Inventory-II scores ranging from 0 to 63 that denote minimal depression at 0-13; mild at 14-19; moderate at 20–28; severe 29–63) as well as State Trait Anxiety Inventory Y1 and Y2 survey results gauging state anxiety score between 20 - 80 and trait anxiety score between 20 - 80"

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Test Retest Reliability of OA and OH

Benedict Alter 2022. "Test Retest Reliability of OA and OH". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05487183.