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Brain MRI Research for Knee Osteoarthritis Pain

N/A

Waitlist Available

Led By Michael D Noseworthy, PhD, PEng

Research Sponsored by Toronto Rehabilitation Institute

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Clinical diagnosis and radiographic evidence of knee OA (by rheumatologist)

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 2 hours

Awards & highlights

Study Summary

This trial will research how chronic pain from osteoarthritis affects the brain in order to develop new treatments for pain relief.

Who is the study for?

This trial is for English-speaking adults with knee osteoarthritis (OA) confirmed by a rheumatologist, who have had chronic knee pain for over 3 months. Participants must not be on psychotropic meds, pregnant, or have liver/kidney disease. They can't have metal implants, claustrophobia, substance abuse issues, fibromyalgia, inflammatory disorders like rheumatoid arthritis or depression.Check my eligibility

What is being tested?

The study uses advanced brain MRI to explore how chronic knee OA pain affects the brain. It aims to identify specific brain areas linked to complex and hard-to-treat aspects of chronic pain in order to guide future treatments targeting these dysfunctions.See study design

What are the potential side effects?

Since this trial involves MRI scans rather than medication or invasive procedures, side effects are minimal but may include discomfort from staying still during the scan and temporary unease due to the cold pressor gel test used.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I have been diagnosed with knee osteoarthritis by a rheumatologist.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 2 hours

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~2 hours

This trial's timeline: 3 weeks for screening, Varies for treatment, and 2 hours for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Group and individual differences at baseline and post-intervention

Secondary outcome measures

Presence of neuroinflammation

Trial Design

3Treatment groups

Experimental Treatment

Active Control

Group I: OA-Knee+BodyExperimental Treatment1 Intervention

Individuals with knee OA with localized knee pain and widespread bodily pain. All participants will complete the same study protocol with pre- post-perturbation MRI scans and pain assessment questionnaires, as well as breath samples collected at multiple time points during the study visit.

Group II: OA-KneeExperimental Treatment1 Intervention

Individuals with knee OA with localized knee pain. All participants will complete the same study protocol with pre- post-perturbation MRI scans and pain assessment questionnaires, as well as breath samples collected at multiple time points during the study visit.

Group III: OA-PFActive Control1 Intervention

Individuals with knee OA without knee or bodily pain. All participants will complete the same study protocol with pre- post-perturbation MRI scans and pain assessment questionnaires, as well as breath samples collected at multiple time points during the study visit.

0 / 1Eligibility criteria met

Find a Location

Who is running the clinical trial?

Toronto Rehabilitation InstituteLead Sponsor

50 Previous Clinical Trials

5,555 Total Patients Enrolled

McMaster UniversityOTHER

880 Previous Clinical Trials

2,597,762 Total Patients Enrolled

Michael D Noseworthy, PhD, PEngPrincipal InvestigatorMcMaster University

1 Previous Clinical Trials

100 Total Patients Enrolled

Media Library

OA-Knee Clinical Trial Eligibility Overview. Trial Name: NCT05986513 — N/A

Central Sensitization Research Study Groups: OA-PF, OA-Knee, OA-Knee+Body

Central Sensitization Clinical Trial 2023: OA-Knee Highlights & Side Effects. Trial Name: NCT05986513 — N/A

OA-Knee 2023 Treatment Timeline for Medical Study. Trial Name: NCT05986513 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are individuals aged 30 or older eligible to partake in this research project?

"Based on the requirements of this investigation, participants must be within the 18-80 year old age bracket. Separately, there are 74 trials available for minors and 1006 dedicated to senior citizens."

Answered by AI

Are there still opportunities for patient enrollment in this investigation?

"Per the information found on clinicaltrials.gov, this trial has reached it's patient recruitment limit and is no longer looking for applicants. Initially posted to the website on September 1st 2023, with a final update made on August 3rd 2023; however, there are still 1086 other studies actively seeking participants at this time."

Answered by AI