Haplo SCT for Acute Myeloid Leukemia

Helsinki University Central Hospital, Helsinki, Finland
Acute Myeloid Leukemiaallogeneic stem cell transplantation with a haplo-identical family donor graft - Other
Eligibility
18+
All Sexes
What conditions do you have?
Select

Study Summary

This trial is ongoing, but not yet recruiting patients.

Eligible Conditions
  • Acute Myeloid Leukemia

Treatment Effectiveness

Phase-Based Effectiveness

1 of 3
N/A

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Study Objectives

1 Primary · 19 Secondary · Reporting Duration: 2 years and 5 years

1 year
Engraftment of thrombocytes
2 years
Bone Transplantation
Acute graft.vs.-host disease
Infection
Intention to treat analysis of 2-year graft-vs.-host disease- and relapse-free survival
Other non-specified transplant complications
Per protocol analysis of 2-year graft-vs.-host disease- and relapse-free survival
Year 5
Bone Transplantation
Disease-free survival
Intention to treat analysis of Disease-free survival
Intention to treat analysis of Overall survival
Overall survival
Per protocol analysis of Disease-free survival
Per protocol analysis of Overall survival
Relapse
5 years
Bone Transplantation
Intention to treat analysis of 5-year graft-vs.-host disease- and relapse-free survival
Per protocol analysis of 5-year graft-vs.-host disease- and relapse-free survival
Secondary malignancies
90 days
Engraftment of neutrophil granulocytes

Trial Safety

Phase-Based Safety

1 of 3

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1
TregGraft (Orca-T)
2
Functional Precision Oncology
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Awards & Highlights

No Placebo Group
All patients enrolled in this trial will receive the new treatment.

Trial Design

2 Treatment Groups

URD SCT
1 of 2
Haplo SCT
1 of 2

Active Control

Experimental Treatment

18 Total Participants · 2 Treatment Groups

Primary Treatment: Haplo SCT · No Placebo Group · N/A

Haplo SCT
Other
Experimental Group · 1 Intervention: allogeneic stem cell transplantation with a haplo-identical family donor graft · Intervention Types: Other
URD SCT
Other
ActiveComparator Group · 1 Intervention: allogeneic stem cell transplantation with a matched unrelated donor graft · Intervention Types: Other

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: 2 years and 5 years

Who is running the clinical trial?

University Hospital, LinkoepingOTHER
168 Previous Clinical Trials
952,579 Total Patients Enrolled
Skane University HospitalOTHER
154 Previous Clinical Trials
82,089 Total Patients Enrolled
Jonas MattssonLead Sponsor
University Hospital, UmeåOTHER
42 Previous Clinical Trials
10,088 Total Patients Enrolled
Karolinska InstitutetLead Sponsor
1,232 Previous Clinical Trials
9,845,714 Total Patients Enrolled
Oslo University HospitalOTHER
1,011 Previous Clinical Trials
1,268,354 Total Patients Enrolled
St. Petersburg State Pavlov Medical UniversityOTHER
51 Previous Clinical Trials
81,653 Total Patients Enrolled
Princess Margaret Hospital, CanadaOTHER
115 Previous Clinical Trials
30,454 Total Patients Enrolled
Medical University of ViennaOTHER
1,070 Previous Clinical Trials
1,805,600 Total Patients Enrolled
Uppsala University HospitalOTHER
152 Previous Clinical Trials
394,144 Total Patients Enrolled
Helsinki University Central HospitalOTHER
402 Previous Clinical Trials
568,509 Total Patients Enrolled
Sahlgrenska University Hospital, SwedenOTHER
378 Previous Clinical Trials
289,034 Total Patients Enrolled
Johan Karlsson Torlen, MD PhDStudy ChairKarolinska Institutet

Eligibility Criteria

Age 18+ · All Participants · 0 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
References

Frequently Asked Questions

Are there any openings still available for participants in the clinical trial?

"Clinicaltrials.gov provides evidence that recruitment for this medical experiment is still underway, with the first posting on 11th December 2019 and most recent edits made in March 2020." - Anonymous Online Contributor

Unverified Answer

What is the aggregate tally of participants in this medical experiment?

"Yes, the information posted on clinicaltrials.gov demonstrates that this medical research is actively recruiting patients. This investigation was originally advertised on November 12th 2019 and has been updated for the last time on February 3rd 2020. 200 individuals need to be enrolled from a single center." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

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