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Procedure

high dialysate flow, larger dialyzer for Kidney Disease

N/A
Waitlist Available
Led By Timothy W Meyer, MD
Research Sponsored by Palo Alto Veterans Institute for Research
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
stable on nocturnal in-center dialysis located close to Stanford University and VA Palo Alto
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up participants will be followed for 2-3 weeks on different dialysis prescriptions and plasma chemical levels will be measured at the end of this period.
Awards & highlights

Study Summary

Hemodialysis keeps patients with renal failure alive but does not restore normal health. Retention of chemicals that bind to plasma proteins and are therefore poorly removed by dialysis may contribute to ill health in patients receiving conventional treatment. This proposal will test the effect of a new method designed to improve the removal of protein-bound solutes during dialysis. The effects on blood chemical levels of two different dialysis prescriptions will be tested in patients already undergoing nocturnal in-center hemodialysis three times weekly.

Eligible Conditions
  • Kidney Disease

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~participants will be followed for 2-3 weeks on different dialysis prescriptions and plasma chemical levels will be measured at the end of this period.
This trial's timeline: 3 weeks for screening, Varies for treatment, and participants will be followed for 2-3 weeks on different dialysis prescriptions and plasma chemical levels will be measured at the end of this period. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Plasma levels of the chemical p-cresol sulfate

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: high dialysate flow, larger dialyzerExperimental Treatment1 Intervention
high dialysate flow, larger dialyzer
Group II: low dialysate flow, smaller dialyzerActive Control1 Intervention
low dialysate flow, smaller dialyzer

Find a Location

Who is running the clinical trial?

Palo Alto Veterans Institute for ResearchLead Sponsor
52 Previous Clinical Trials
7,881 Total Patients Enrolled
Timothy W Meyer, MDPrincipal InvestigatorPAIRE
1 Previous Clinical Trials
30 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Increasing the Removal of Protein-Bound Solutes During Extended Hours Hemodialysis
2013. "Increasing the Removal of Protein-Bound Solutes During Extended Hours Hemodialysis". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT01892839.
All > Dialysis
~2 spots leftby May 2025
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