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Antiseptic Mouth Rinse

Antiseptic Mouth Rinses for COVID-19 (MOR2 Trial)

N/A

Recruiting

Led By Laura A Jacox, DMD, PhD

Research Sponsored by University of North Carolina, Chapel Hill

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline, 30 minutes

Awards & highlights

MOR2 Trial Summary

This trial is testing whether or not therapeutic, antiseptic mouth rinses can inactivate the severe acute respiratory syndrome coronavirus (SARS-CoV-2) in saliva of COVID-19 positive patients.

Who is the study for?

This trial is for COVID-19 positive individuals aged 18-65 in good oral health, without allergies to dental products. They must understand the study and not be pregnant or have severe medical conditions. Excluded are those with recent oral infections, on lithium therapy, alcohol consumption within 12 hours of the visit, eating/drinking an hour before the study, or history of drug abuse.Check my eligibility

What is being tested?

The MOR2 trial tests if antiseptic mouth rinses can deactivate SARS-CoV-2 in saliva. Participants will use a mouthwash once and provide saliva samples over an hour to check for viral RNA. The study compares sterile water, ethanol with essential oils, and cetylpyridinium chloride.See study design

What are the potential side effects?

Potential side effects may include allergic reactions to ingredients like iodine or ethanol in mouth rinses and discomfort from taste or sensation during use. However, since these are commercial products used as directed on labels, significant side effects are unlikely.

MOR2 Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline, 30 minutes

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline, 30 minutes

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, 30 minutes for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Change in Quantitative Polymerase Chain Reaction (qPCR) from Baseline to 15 Minutes

Change in Quantitative Polymerase Chain Reaction (qPCR) from Baseline to 30 Minutes

MOR2 Trial Design

3Treatment groups

Active Control

Placebo Group

Group I: 27% Ethanol plus essential oilsActive Control1 Intervention

Subject participants will rinse mouth one time for 60 seconds with 20 mL 27% ethanol plus essential oils.

Group II: 0.075% Cetylpyridinium ChlorideActive Control1 Intervention

Subject participants will rinse mouth one time for 60 seconds with 20 mL 0.075% Cetylpyridinium Chloride.

Group III: Sterile WaterPlacebo Group1 Intervention

Subject participants will rinse mouth one time for 60 seconds with 20 mL of sterile water.

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

University of North Carolina, Chapel HillLead Sponsor

1,504 Previous Clinical Trials

4,187,512 Total Patients Enrolled

10 Trials studying COVID-19

3,645 Patients Enrolled for COVID-19

Laura A Jacox, DMD, PhDPrincipal InvestigatorUniversity of North Carolina Adams School of Dentistry

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

May I be admitted into this experiment?

"This coronavirus study requires 150 participants aged between 18 and 65 with an active covid-19 infection. The candidates must be capable of understanding the protocol and fulfilling its demands, including being present on the days specified by researchers. In addition to this, they should not have any pre-existing allergies or oral health issues, as well as belong to American Society of Anesthesiologists (ASA) class I or II prior to contracting Covid-19."

Answered by AI

Is enrollment still possible for this research endeavor?

"Affirmative. The clinicaltrials.gov records verify that this research is actively searching for participants, which was initially posted on the 20th of January 2022 and updated lastly on 7th February 2021. This investigation necessitates 150 individuals from 1 site to be recruited."

Answered by AI

What is the aggregate size of those participating in this experiment?

"Affirmative. According to information located on clinicaltrials.gov, this investigation is actively searching for potential participants. It was initially posted on January 20th 2022 and underwent a recent update on February 7th 2022; it requires 150 enrollees from one medical centre"

Answered by AI

Is the age criteria for this scientific research confined to those over seventy years old?

"This trial only admits participants aged between 18 and 65; however, there are alternative trials available for people outside that age bracket--336 of them are tailored to the under-18 group whereas 1460 cater to those above the age of 65."

Answered by AI

Recent research and studies

British Dental JournalJournal

Povidone Iodine

Challacombe, S. J., J. Kirk-Bayley, V. S. Sunkaraneni, and J. Combes. 2020. “Povidone Iodine”. British Dental Journal. Springer Science and Business Media LLC. doi:10.1038/s41415-020-1589-4.

JamaJournal

Interpreting Diagnostic Tests for Sars-cov-2

Sethuraman, Nandini, Sundararaj Stanleyraj Jeremiah, and Akihide Ryo. 2020. “Interpreting Diagnostic Tests for Sars-cov-2”. Jama. American Medical Association (AMA). doi:10.1001/jama.2020.8259.

Journal of Dental ResearchJournal

COVID-19 Transmission in Dental Practice: Brief Review of Preventive Measures in Italy

Izzetti, R., M. Nisi, M. Gabriele, and F. Graziani. 2020. “COVID-19 Transmission in Dental Practice: Brief Review of Preventive Measures in Italy”. Journal of Dental Research. SAGE Publications. doi:10.1177/0022034520920580.

FunctionJournal