Shampoo and Listerine for Coronavirus

Phase-Based Progress Estimates
1
Effectiveness
2
Safety
Coronavirus+1 MoreShampoo and Listerine - CombinationProduct
Eligibility
18 - 65
All Sexes
What conditions do you have?
Select

Study Summary

This trial is testing whether a 4-day combined intervention of nasal washes with 1% baby shampoo solution and oral gargles with Listerine Antiseptic can reduce the SARS-CoV-2 viral load compared to those using nasal and oral washes with normal saline.

Eligible Conditions
  • Coronavirus

Treatment Effectiveness

Study Objectives

1 Primary · 6 Secondary · Reporting Duration: 6 days

1 day
Levels of live virus (viral infectivity titer)
5 days
4-day trend in viral load change
Compliance as measured by percent of expected washes completed
Compliance as measured by percentage of randomized participants that withdrew consent and elected not to continue in the study.
The tolerability of the intervention measured using the validated Sino-nasal outcome test (SNOT-22) scale.
Viral Load Change from baseline
6 days
Acceptability of the intervention as measured by 7 item questionnaire based an acceptability framework described by Sekhon (2017)

Trial Safety

Safety Progress

2 of 3
This is further along than 68% of similar trials

Trial Design

4 Treatment Groups

Listerine Gargle
1 of 4
Baby Shampoo Nasal Wash
1 of 4
Combination of Baby Shampoo Nasal Wash and Listerine Gargle
1 of 4
Saline Wash and Gargles
1 of 4

Active Control

Experimental Treatment

Non-Treatment Group

200 Total Participants · 4 Treatment Groups

Primary Treatment: Shampoo and Listerine · Has Placebo Group · Phase 2 & 3

Combination of Baby Shampoo Nasal Wash and Listerine Gargle
CombinationProduct
Experimental Group · 1 Intervention: Shampoo and Listerine · Intervention Types: CombinationProduct
Listerine Gargle
CombinationProduct
ActiveComparator Group · 1 Intervention: Saline and Listerine · Intervention Types: CombinationProduct
Saline Wash and Gargles
CombinationProduct
PlaceboComparator Group · 1 Intervention: Saline and Saline · Intervention Types: CombinationProduct
Baby Shampoo Nasal Wash
CombinationProduct
ActiveComparator Group · 1 Intervention: Shampoo and saline · Intervention Types: CombinationProduct

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: 6 days

Who is running the clinical trial?

AXIOM Real Time MetricsUNKNOWN
3 Previous Clinical Trials
545 Total Patients Enrolled
Milton S. Hershey Medical CenterLead Sponsor
462 Previous Clinical Trials
2,784,527 Total Patients Enrolled
Analytica Ventures LLCUNKNOWN
Rena Kass, MDPrincipal InvestigatorPenn State College of Medicine

Eligibility Criteria

Age 18 - 65 · All Participants · 4 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
I am currently in isolation
You are an adult who is ≥18 - 65 years of age.
A person who tests positive for the SARS-CoV-2 virus within 5 days of enrolling in a study is more likely to experience a severe illness.
Symptomatic people have fever and cough
References