Study of Langerhans Cell Histiocytosis
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to better understand histiocytic disorders by collecting medical histories, blood, and tissue samples from participants. Histiocytic disorders involve abnormal growth of certain immune cells, causing various health issues. Researchers will use this information for current and future studies to develop better treatments. Individuals diagnosed with a histiocytic disorder and over one year old are eligible to join. Participants will complete questionnaires and provide samples for research.
As an unphased trial, this study offers participants the chance to contribute to groundbreaking research that could lead to improved treatments for histiocytic disorders.
Do I need to stop my current medications for this trial?
The trial information does not specify whether you need to stop taking your current medications.
Why are researchers excited about this trial?
Researchers are excited about this trial because it offers a deeper dive into understanding histiocytic disorders at a molecular level, which could pave the way for more targeted therapies in the future. Unlike traditional treatments that focus on managing symptoms, this trial emphasizes collecting comprehensive data from patients, including blood and tissue samples, as well as detailed medical histories. This approach could lead to identifying new biomarkers or genetic factors that contribute to these disorders, potentially revolutionizing how they are diagnosed and treated.
Who Is on the Research Team?
Ronald S. Go, M.D.
Principal Investigator
Mayo Clinic in Rochester
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Baseline Assessment
Patients complete questionnaires and undergo blood and tissue sample collection. Patients' medical records are also reviewed.
Observational Follow-up
Blood testing will be performed for soluble PD-L1 and T-cell Bim expressions before and after radiation therapy for histiocytic disease to assess change in levels and role of immunotherapy.
Molecular Analysis
Biopsy samples will be analyzed for the presence of molecular markers associated with histiocytic disorders.
What Are the Treatments Tested in This Trial?
Interventions
- Non-Interventional Study
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
Patients complete questionnaires and undergo blood and tissue sample collection. Patients' medical records are also reviewed.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Mayo Clinic
Lead Sponsor
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