Resistance Training for Obesity

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
University of Alabama at Birmingham, Birmingham, AL
Obesity+1 More
Resistance Training - Behavioral
Eligibility
18+
All Sexes
Eligible conditions
Select

Study Summary

This study is evaluating whether a high protein diet and resistance training may help improve body composition in older adults.

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Eligible Conditions

  • Obesity

Treatment Effectiveness

Study Objectives

This trial is evaluating whether Resistance Training will improve 8 primary outcomes, 5 secondary outcomes, and 6 other outcomes in patients with Obesity. Measurement will happen over the course of Week 8..

Baseline
1st Stage Intervention Preference
Baseline through week 52.
Class Attendance
Recruitment and Retention Rates
Week 8
Change in fat free mass
Change in fat mass
Week 8
Change in glucose
Change in insulin
Changes in aerobic fitness
Changes in disposition index
Changes in lipids
Changes in muscle health of hands and forearms and in overall strength
Changes in physical activity
Week 8
Body Weight
Fat free mass
Fat mass
Baseline.
1st Stage Treatment Credibility
Week 16 to 52
Changes in body composition
Week 8
2nd Stage Intervention Preference
Week 8.
2nd Stage Treatment Credibility

Trial Safety

Trial Design

2 Treatment Groups

High Protein Diet
1 of 2
Resistance Training
1 of 2
Experimental Treatment

This trial requires 90 total participants across 2 different treatment groups

This trial involves 2 different treatments. Resistance Training is the primary treatment being studied. Participants will be divided into 2 treatment groups. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

High Protein Diet
Behavioral
Enrollment in State of Slim (SOS) weight loss program with a high protein diet.
Resistance Training
Behavioral
Enrollment in State of Slim (SOS) weight loss program with resistance training counseling sessions.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Resistance Training
2019
Completed Phase 2
~1290
High Protein Diet
2017
N/A
~200

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: baseline
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly baseline for reporting.

Who is running the study

Principal Investigator
D. S.
Drew Sayer, Primary Investigator
University of Alabama at Birmingham

Closest Location

University of Alabama at Birmingham - Birmingham, AL

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. There are 6 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
BMI of 25-50 kg/m2 for wheelchair users (less than or equal to 350 lbs.)
Male or Female
Age ≥50 years
Post-menopausal if Female
BMI of 30-50 kg/m2 for ambulatory participants (less than or equal to 350 lbs.)
Ambulatory with or without a walking device or use of a manual wheelchair for mobility.

Patient Q&A Section

How many people get weight loss a year in the United States?

"About 14.6 million US adults lost at least 10% of a baseline weight and 0.8 million lost 22% or more of a baseline weight in the previous 12 months. Most of these were employed adults who had no medical condition.\n" - Anonymous Online Contributor

Unverified Answer

What causes weight loss?

"Weight loss is often caused by many different factors, most importantly excessive calorie intake. Factors that may not directly lead to weight loss can play a role (such as decreased activity levels) in the ultimate weight loss. A low protein diet can cause a significant amount of weight loss." - Anonymous Online Contributor

Unverified Answer

What are common treatments for weight loss?

"This article discusses what constitutes proper diet and exercises for weight loss and the more dramatic use of behavioral changes of diet and exercise that may be a last resort for extreme weight losses." - Anonymous Online Contributor

Unverified Answer

What are the signs of weight loss?

"Weight loss can have a variety of effects on individuals; however, there is no direct connection between cause and effect. Weight loss can be provoked by numerous factors: the loss of weight itself may be a result of the decrease in energy intake, resulting from a loss of appetite, due to a reduction in physical activity. The loss of body fat leads to the loss of energy stores; a state of 'energy starvation'. The 'anorexia' phase is characterized by a reduction in appetite, due to the loss of body fat, in order to conserve energy stores for physical activity. When physical activity is discontinued, a state of'malnutrition' can result." - Anonymous Online Contributor

Unverified Answer

What is weight loss?

"To date, the main clinical use of bariatric surgical procedures has been the reduction of obesity. Other possible indications could be obesity-related diabetes, dyslipidemia, weight regain after failure of pharmacological or behavioral treatment, and other types of bariatric surgical procedures. However, further research is needed." - Anonymous Online Contributor

Unverified Answer

Can weight loss be cured?

"Although some patients lose 5 to 10 kg, the majority show little change in weight or waist circumference 1 year after surgery for a mean weight loss of 3.4 kg. Complications are more common among the remaining patients and are mainly connected with the degree to which the band has constricted the intestines." - Anonymous Online Contributor

Unverified Answer

How does resistance training work?

"Resistance training is as effective as aerobic exercise and dietary changes and decreases muscle lipogenic enzymes in human skeletal muscle, an effect that is not sustained long after the cessation of the training program. These changes would be expected to increase the likelihood of glucose uptake and muscle glucose metabolism even in the presence of caloric excess. Therefore, it is concluded that resistance exercise may be useful for reducing muscle lipid overconsumption in some types of muscle hypertrophy; however, this does not seem to have any other beneficial effects on leanness or muscle metabolism." - Anonymous Online Contributor

Unverified Answer

What are the latest developments in resistance training for therapeutic use?

"Exercise resistance training and its associated exercise equipment and equipment accessories have seen many changes over the recent years in the fields of training methodology, equipment type, exercise purpose, exercise volume and intensity; most importantly, exercise programming systems. This article presents these emerging trends and relates them to the scientific basis behind therapeutic resistance exercise." - Anonymous Online Contributor

Unverified Answer

What does resistance training usually treat?

"Resistance training may increase aerobic exercise capacity, but the lack of differences in most measures of cardiovascular fitness suggests that cardiovascular and skeletal adaptations are similar or the latter may be improved by resistance training." - Anonymous Online Contributor

Unverified Answer

What is the primary cause of weight loss?

"People who want to lose weight do. While not every cause is known, the primary cause of weight loss is the fact that people are not hungry and when they do overeat, they eat more than they should. Weight loss is a response to this eating behavior. Dieters need to focus on eating the right amount of calories and the right amount of fat to achieve a lean body mass and keep from gaining more weight again. When food is eaten without awareness of the calories and fat content, many people are unaware of where they are going wrong. Dieters need to realize that dieting doesn’t just fix the body, it’s the way the body is constructed." - Anonymous Online Contributor

Unverified Answer

Does weight loss run in families?

"Weight control was improved by parental involvement with their children's weight control, although the effects of familial resemblance were negligible. Interventions for weight control ought to include family members in addition to the overweight/obese individual." - Anonymous Online Contributor

Unverified Answer

Does resistance training improve quality of life for those with weight loss?

"Results from a recent paper suggest that resistance training can have a positive impact on psychological variables such as quality of life in morbidly obese patients with weight loss after bariatric surgery." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
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