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Oral food desensitization for Eosinophilic Esophagitis

N/A

Waitlist Available

Research Sponsored by The University of Texas Health Science Center, Houston

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be younger than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 5 months

Awards & highlights

Study Summary

This trial is testing whether it's safe to desensitize kids with EoE to their trigger food, with the hope that it will be effective.

Eligible Conditions

Eosinophilic Esophagitis

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 5 months

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~5 months

This trial's timeline: 3 weeks for screening, Varies for treatment, and 5 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Peak eosinophil count on esophageal biopsy

Trial Design

1Treatment groups

Experimental Treatment

Group I: Oral food desensitizationExperimental Treatment1 Intervention

All of the children enrolled in the study will receive oral food desensitization with his or her specific EoE flare-inducing food antigen (e.g. cow's milk protein). The food antigen will be diluted in a 50% glycerin/water solution containing ascorbic acid (Vitamin C) to stabilize and preserve the solution. This oral spray will need to be administered twice a day, every day for a total of 4 months.

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Who is running the clinical trial?

The University of Texas Health Science Center, HoustonLead Sponsor

903 Previous Clinical Trials

320,972 Total Patients Enrolled

3 Trials studying Eosinophilic Esophagitis

164 Patients Enrolled for Eosinophilic Esophagitis

Marc Rhoads, MDStudy DirectorUniversity of Texas

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the qualifications for enrollment in this clinical experiment?

"The study requires participants between 3 and 17 years old to be diagnosed with eosinophilic esophagitis. Five children will be recruited in total."

Answered by AI

Does this clinical trial extend to elderly participants over the age of 65?

"The desired age range for participants of this research is between 3 and 17 years old."

Answered by AI

What is the aggregate number of participants involved in this clinical trial?

"Yes, the public records found on clinicaltrials.gov demonstrate that this experiment is actively recruiting patients. This trial was originally posted in August of 2018 and has since been modified as recently as June 2021 with a target enrolment of 5 participants from one site."

Answered by AI

Is this research endeavor recruiting new participants currently?

"Affirmative. Data hosted on clinicaltrials.gov points to the fact that this medical trial, whose inception was August 8th 2018, is now actively looking for individuals to take part in it. The team needs 5 participants from a single medical centre."

Answered by AI

Recent research and studies

Gastrointestinal Endoscopy Clinics of North AmericaJournal

Noninvasive Markers of Eosinophilic Esophagitis

Gupta, Sandeep K.. 2008. “Noninvasive Markers of Eosinophilic Esophagitis”. Gastrointestinal Endoscopy Clinics of North America. Elsevier BV. doi:10.1016/j.giec.2007.09.004.

Journal of Allergy and Clinical ImmunologyJournal

Pediatric Eosinophilic Esophagitis Symptom Scores (PEESS V2.0) Identify Histologic and Molecular Correlates of the Key Clinical Features of Disease

Martin, Lisa J., James P. Franciosi, Margaret H. Collins, J. Pablo Abonia, James J. Lee, Kevin A. Hommel, James W. Varni, et al.. 2015. “Pediatric Eosinophilic Esophagitis Symptom Scores (PEESS V2.0) Identify Histologic and Molecular Correlates of the Key Clinical Features of Disease”. Journal of Allergy and Clinical Immunology. Elsevier BV. doi:10.1016/j.jaci.2015.03.004.

Alimentary Pharmacology & TherapeuticsJournal

Systematic Review with Meta-analysis: The Incidence and Prevalence of Eosinophilic Oesophagitis in Children and Adults in Population-based Studies

Arias, Á., I. Pérez-Martínez, J. M. Tenías, and A. J. Lucendo. 2015. “Systematic Review with Meta-analysis: The Incidence and Prevalence of Eosinophilic Oesophagitis in Children and Adults in Population-based Studies”. Alimentary Pharmacology & Therapeutics. Wiley. doi:10.1111/apt.13441.

AllergyJournal