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Household Detergents and Eosinophilic Esophagitis

N/A

Waitlist Available

Led By Benjamin Wright, MD

Research Sponsored by Mayo Clinic

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline, 15 minutes after teeth brushing

Awards & highlights

Study Summary

This trial will study whether common household cleaning products can cause inflammation of the esophagus and trigger allergies.

Who is the study for?

This trial is for healthy volunteers who can swallow pills. It's not for those with a history of esophageal diseases, swallowing difficulties, chronic abdominal issues, certain digestive disorders, gelatin allergies, recent use of SLS toothpaste or those who are pregnant.Check my eligibility

What is being tested?

The study investigates if detergents like those in Colgate toothpaste contribute to allergic inflammation by making the esophagus lining leaky. Participants will undergo an Esophageal String Test and High Resolution Esophageal Manometry.See study design

What are the potential side effects?

Potential side effects may include discomfort from swallowing the string used in EST or mild irritation from manometry procedures. Allergic reactions to ingredients in tested products could also occur.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline, 15 minutes after teeth brushing

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline, 15 minutes after teeth brushing

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, 15 minutes after teeth brushing for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Change in Mucosal impedance 15 minutes after exposure

Secondary outcome measures

Change in IL-33 levels

Cardiography, Impedance

Change in Mucosal impedance 45 minutes after exposure

+1 more

Trial Design

1Treatment groups

Experimental Treatment

Group I: Toothpaste detergents with Eosinophilic Esophagitis TestingExperimental Treatment3 Interventions

Subjects will complete an esophageal string test prior to and after completing a high resolution esophageal manometry then brushing their teeth using Colgate toothpaste.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Esophageal String Test (EST)

2018

N/A

~30

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Mayo ClinicLead Sponsor

3,205 Previous Clinical Trials

3,766,772 Total Patients Enrolled

25 Trials studying Eosinophilic Esophagitis

1,479 Patients Enrolled for Eosinophilic Esophagitis

Benjamin Wright, MDPrincipal InvestigatorMayo Clinic

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Has this experiment reached its participant capacity?

"According to the records on clinicaltrials.gov, this experiment is actively recruiting participants since its first posting date of September 12th 2022 and most recent update from September 22nd 2022."

Answered by AI

What is the current patient count for this particular research endeavor?

"Indeed, according to clinicaltrials.gov, this active study was first posted on September 12th 2022 and updated recently on the 22nd of that month. The research effort is seeking 10 volunteers across a single medical facility."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

A Study of Detergents in the Pathogenesis of Eosinophilic Esophagitis

Benjamin L. Wright 2022. "A Study of Detergents in the Pathogenesis of Eosinophilic Esophagitis". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05482256.

All > Eosinophilic Esophagitis