Esophageal String Test (EST) for Eosinophilic Esophagitis

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Mayo Clinic Arizona, Scottsdale, AZ
Eosinophilic Esophagitis+1 More
Esophageal String Test (EST) - DiagnosticTest
Eligibility
18+
All Sexes
What conditions do you have?
Select

Study Summary

The purpose of this research is to determine if detergents in everyday products such as toothpaste make the lining of the esophagus leaky and cause allergic inflammation.

Eligible Conditions

  • Eosinophilic Esophagitis

Treatment Effectiveness

Effectiveness Progress

1 of 3

Other trials for Eosinophilic Esophagitis

Study Objectives

1 Primary · 4 Secondary · Reporting Duration: Baseline, 15 minutes after teeth brushing

Baseline, 15 minutes after teeth brushing
Change in Mucosal impedance 15 minutes after exposure
Baseline, 30 minutes after teeth brushing
Change in Mucosal impedance 30 minutes after exposure
Baseline, 45 minutes after teeth brushing
Change in Mucosal impedance 45 minutes after exposure
Baseline, 60 minutes after teeth brushing
Change in Mucosal impedance 60 minutes after exposure
Baseline, approximately 60 minutes after teeth brushing
Change in IL-33 levels

Trial Safety

Safety Progress

1 of 3

Other trials for Eosinophilic Esophagitis

Trial Design

1 Treatment Group

Toothpaste detergents with Eosinophilic Esophagitis Testing
1 of 1
Experimental Treatment

10 Total Participants · 1 Treatment Group

Primary Treatment: Esophageal String Test (EST) · No Placebo Group · N/A

Toothpaste detergents with Eosinophilic Esophagitis TestingExperimental Group · 3 Interventions: Esophageal String Test (EST), High Resolution Esophageal Manometry (HREM), Colgate · Intervention Types: DiagnosticTest, DiagnosticTest, Other
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Esophageal String Test (EST)
2018
N/A
~30

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: baseline, 15 minutes after teeth brushing
Closest Location: Mayo Clinic Arizona · Scottsdale, AZ
Photo of mayo clinic arizona 1Photo of mayo clinic arizona 2Photo of mayo clinic arizona 3
2005First Recorded Clinical Trial
2 TrialsResearching Eosinophilic Esophagitis
150 CompletedClinical Trials

Who is running the clinical trial?

Mayo ClinicLead Sponsor
2,860 Previous Clinical Trials
3,686,151 Total Patients Enrolled
24 Trials studying Eosinophilic Esophagitis
1,509 Patients Enrolled for Eosinophilic Esophagitis
Benjamin Wright, MDPrincipal InvestigatorMayo Clinic

Eligibility Criteria

Age 18+ · All Participants · 2 Total Inclusion Criteria

Mark “yes” if the following statements are true for you:
You are a healthy, normal, young adult.

About The Reviewer

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 9th, 2021

Last Reviewed: August 12th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.