Music Intervention for Chronic Pain

Recruiting at 1 trial location

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: Lake Erie College of Osteopathic Medicine

Disqualifiers: Hearing impairment, Sensitivity to music

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Approved in 1 Jurisdiction This treatment is already approved in other countries

Compensation: Varies

Number of Visits: 2

Duration: 1 day

100 Participants Needed

What You Need to Know Before You Apply

What is the purpose of this trial?

The purpose of this study is to determine if the use of musical intervention reduces patient anxiety and provides a less painful experience during office-based procedures in a pain management clinic setting.

Do I need to stop my current medications for the trial?

The trial information does not specify whether you need to stop taking your current medications.

Is music intervention safe for humans?

Music interventions, like group singing and music therapy, have been studied for chronic pain and are generally considered safe. They can improve well-being and reduce pain without significant side effects. ^{1 2 3 4 5}

How does the music intervention treatment for chronic pain differ from other treatments?

The music intervention treatment for chronic pain is unique because it involves group song-making, which can enhance psychological well-being and social connections, unlike traditional treatments that often focus solely on medication. This approach uses music to alter mood and provide distraction, offering a non-drug alternative that can improve self-management of pain. ^{1 3 6 7 8}

What data supports the effectiveness of the treatment Musical Intervention, Song-making In a Group (SING), Musical Intervention (MI) for chronic pain?

Research shows that music therapy, including group singing and vocal music therapy, can help manage chronic pain by improving mood, reducing anxiety and depression, and enhancing social connections. Studies have found that these interventions can lead to significant improvements in self-efficacy (confidence in managing pain) and the ability to participate in social activities. ^{1 6 8 9 10}

Who Is on the Research Team?

Kamal Patel, MD

Principal Investigator

NeuSpine Institute, Florida

Are You a Good Fit for This Trial?

This trial is for individuals with chronic pain who are scheduled for an office-based procedure and have signed informed consent. It's not suitable for those with major hearing impairments or sensitivity to music.

Inclusion Criteria

Informed consent is signed by a subject

I have a procedure planned at the doctor's office.

Exclusion Criteria

Major hearing impairment

Sensitivity to music

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

1-2 weeks

Treatment

Participants undergo office-based procedures with or without musical intervention to assess pain and anxiety levels

1 day

1 visit (in-person)

Follow-up

Participants are monitored for immediate effects on pain and anxiety levels after the procedure

Immediately after procedure

1 visit (in-person)

What Are the Treatments Tested in This Trial?

Interventions

• Musical Intervention

Trial Overview The study aims to see if playing music during a procedure can help reduce anxiety and pain compared to having the same procedure without music in a clinic that manages chronic pain.

How Is the Trial Designed?

Group I: Music Intervention Experimental Treatment 1 Intervention

A patient is scheduled for an office-based procedure such as a nerve block, epidural steroid injection, etc. Music-of-choice during the office-based procedure intervention is assigned to this group. Music via external speakers played in the procedure room. To ensure acute pain and anxiety control, participants will receive standard analgesic treatment in the beginning of their scheduled interventional procedure. Such treatment includes injection and topical application of lidocaine to induce local anesthesia. Standard of care is applied.

Group II: Control Experimental Treatment 1 Intervention

A patient is scheduled for an office-based procedure such as a nerve block, epidural steroid injection, etc. No music intervention is assigned to this group. No music at any time during the procedure. To ensure acute pain and anxiety control, participants will receive standard analgesic treatment in the beginning of their scheduled interventional procedure. Such treatment includes injection and topical application of lidocaine to induce local anesthesia. Standard of care is applied.

Musical Intervention is already approved in United States for the following indications:

Approved in United States as Musical Intervention for:

• Psychotic illnesses
• Conditioned Hallucinations
• Social Reinforcement Learning
• Language Use

Who Is Running the Clinical Trial?

Lake Erie College of Osteopathic Medicine

Lead Sponsor

Trials

9

Recruited

570+

Published Research Related to This Trial

A 12-week vocal music therapy (VMT) program showed significant benefits in managing chronic pain, with large treatment effects observed in self-efficacy, depression, and social activity participation among 43 predominantly Black female participants.

Qualitative feedback indicated that VMT improved participants' self-management of pain and enhanced their psychological well-being and social connections, despite challenges in recruitment and a 23% attrition rate.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Vocal Music Therapy for Chronic Pain: A Mixed Methods Feasibility Study. Low, MY., Lacson, C., Zhang, F., et al.[2020]

Music therapy is an effective non-drug approach for managing pain and symptoms in patients with long-term and life-threatening illnesses, helping to reduce pain perception through distraction and mood enhancement.

The article reviews various methods and techniques of music therapy, supported by case studies that illustrate its practical application in pain management.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Music therapy in pain and symptom management. Magill-Levreault, L.[2022]

A pilot study involving 4 outpatients with chronic pain showed that participating in 10 weekly group singing sessions provided multiple benefits, including physical, psychological, and social improvements.

The findings suggest that group singing can effectively complement traditional pain management strategies, potentially enhancing overall clinical outcomes for individuals living with chronic pain.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Group Singing Has Multiple Benefits in the Context of Chronic Pain: An Exploratory Pilot Study. Irons, JY., Kuipers, P., Wan, A., et al.[2021]

Music-imaginative Pain Treatment (MIPT) encourages patients to express their pain through music, promoting self-reflection and active engagement, which can be beneficial in managing chronic pain disorders.

In this case study of a 46-year-old woman, early childhood stress was identified as a significant factor influencing her chronic pain, highlighting the importance of addressing psychological and social trauma in pain management therapies.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

The impact of music-imaginative pain treatment (MIPT) on psychophysical affect regulation - A single case study. Glomb, S., Böckelmann, I., Frommer, J., et al.[2022]

In a study involving 12 patients with fibromyalgia and other pain syndromes, active music therapy significantly reduced pain intensity and pain-related disability compared to a control group.

The study suggests that music therapy particularly enhances the emotional and communicative aspects of managing chronic pain, although it did not show changes in depression and anxiety scores.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

[Active music therapy for chronic pain: a prospective study]. Müller-Busch, HC., Hoffmann, P.[2006]

In a study involving 87 patients with chronic pain conditions, a music intervention significantly reduced pain levels after 60 days compared to standard treatment alone, demonstrating its efficacy in pain management.

The music intervention also led to a notable decrease in anxiety and depression, as well as reduced use of anxiolytic medications, highlighting its potential as a complementary therapy for chronic pain patients.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

The effects of music intervention in the management of chronic pain: a single-blind, randomized, controlled trial. Guétin, S., Giniès, P., Siou, DK., et al.[2012]

Citations

1. United States pubmed.ncbi.nlm.nih.gov

Vocal Music Therapy for Chronic Pain: A Mixed Methods Feasibility Study. [2020]

2. United States pubmed.ncbi.nlm.nih.gov

Music therapy in pain and symptom management. [2022]

3. United States pubmed.ncbi.nlm.nih.gov

Group Singing Has Multiple Benefits in the Context of Chronic Pain: An Exploratory Pilot Study. [2021]

4. England pubmed.ncbi.nlm.nih.gov

Feasibility of Music and Hypnotic Suggestion to Manage Chronic Pain. [2018]

5. United States pubmed.ncbi.nlm.nih.gov

Music-Induced Analgesia in Chronic Pain Conditions: A Systematic Review and Meta-Analysis. [2022]

6. Switzerland pubmed.ncbi.nlm.nih.gov

The impact of music-imaginative pain treatment (MIPT) on psychophysical affect regulation - A single case study. [2022]

7. Germany pubmed.ncbi.nlm.nih.gov

[Active music therapy for chronic pain: a prospective study]. [2006]

8. Switzerland pubmed.ncbi.nlm.nih.gov

Case Report: "I got my brain back" A patient's experience with music-induced analgesia for chronic pain. [2023]

9. Switzerland pubmed.ncbi.nlm.nih.gov

Efficacy, Treatment Characteristics, and Biopsychological Mechanisms of Music-Listening Interventions in Reducing Pain (MINTREP): Study Protocol of a Three-Armed Pilot Randomized Controlled Trial. [2020]

10. United States pubmed.ncbi.nlm.nih.gov

The effects of music intervention in the management of chronic pain: a single-blind, randomized, controlled trial. [2012]