Exercise Training for Amyloid Cardiomyopathy
Trial Summary
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications. However, participants in aim 2 must be taking tafamidis, so you may need to continue that medication if you are already on it.
What data supports the effectiveness of this treatment for amyloid cardiomyopathy?
Is exercise training safe for people with heart conditions?
How does exercise training differ from other treatments for amyloid cardiomyopathy?
Exercise training is unique because it focuses on improving heart function and overall health through physical activity, rather than using medications or surgery. It includes endurance, resistance, and respiratory exercises, which can enhance exercise capacity, quality of life, and reduce hospitalizations, making it a holistic approach compared to traditional treatments.1112131415
What is the purpose of this trial?
Transthyretin cardiac amyloidosis causes debilitating heart failure in older adults. The proposed research will develop a personalized exercise training program to improve functional capacity in patients on optimal treatment for transthyretin cardiac amyloidosis. This is a vital next step to improve functional capacity and quality of life of people suffering from transthyretin cardiac amyloidosis.
Eligibility Criteria
This trial is for older adults with transthyretin cardiac amyloidosis who can walk and are independent in daily activities. They must be on stable medical treatment, not already doing regular intense exercise, and have heart failure symptoms with a specific biomarker level. People with certain other health conditions or devices like pacemakers that limit exercise aren't eligible.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo 12 weeks of supervised personalized exercise training to improve functional capacity
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Exercise Training
Find a Clinic Near You
Who Is Running the Clinical Trial?
Brigham and Women's Hospital
Lead Sponsor