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Contingency Management for Alcoholism in Severe Mental Illness

N/A
Waitlist Available
Led By Michael G McDonell, PhD
Research Sponsored by Washington State University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
DSM-5 diagnosis of schizophrenia or schizoaffective disorder, bipolar I or II, or recurrent major depressive disorder (>1 episode)
4 or more standard drinks for females (AFAB)/ 5 or more standard drinks for males (AMAB) on 5 or more occasions in the past 30 days
Must not have
Inability to provide informed consent as measured by the MacCAT-CR (e.g. dementia)
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, week 4, 8, 12, 16 through study completion
Awards & highlights

Summary

This trial will study whether two different approaches to contingency management (CM) can help reduce heavy drinking among people with serious mental illness and alcohol dependence who are seen at community mental health centers.

Who is the study for?
This trial is for adults aged 18-65 with serious mental illness and alcohol dependence, who drink heavily. It's open to those diagnosed with schizophrenia, schizoaffective disorder, bipolar I or II, or recurrent major depressive disorder. Pregnant individuals or those at risk of severe alcohol withdrawal symptoms are excluded.Check my eligibility
What is being tested?
The study tests two contingency management (CM) interventions—High-Magnitude CM and Shaping CM—to treat heavy drinking in the severely mentally ill within a community health setting. Participants will be randomly assigned to one of these treatment conditions.See study design
What are the potential side effects?
While specific side effects are not listed for the CM interventions being tested, participants may experience stress or anxiety due to changes in their routine or as a reaction to the therapy process.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I have been diagnosed with schizophrenia, schizoaffective disorder, bipolar disorder, or recurrent major depression.
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I have had 4+/5+ drinks on 5+ days in the last month.
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I am between 18 and 65 years old.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I am able to understand and agree to the study's requirements.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, week 4, 8, 12, 16 through study completion
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, week 4, 8, 12, 16 through study completion for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Alcohol Use Disorder
Secondary outcome measures
Addiction Severity Index (ASI)
Alcohol and Cigarette Timeline Followback
Brief HIV Risk Behavior Scale
+4 more
Other outcome measures
NIH Toolbox Cognition battery
NIH Toolbox Emotion battery
Obsessive-Compulsive Drinking Scale
+3 more

Trial Design

3Treatment groups
Experimental Treatment
Group I: Usual CMExperimental Treatment1 Intervention
Participants will earn at least 3 prize draws each time they submit an alcohol negative urine samples during weeks 5-20, plus treatment as usual
Group II: Shaping CMExperimental Treatment1 Intervention
Participants will earn prize draws for light drinking during weeks 5-8 instead of alcohol abstinence and will then earn prize draws for abstinence during weeks 9-20, plus treatment as usual.
Group III: High-Magnitude CMExperimental Treatment1 Intervention
Participants will earn twice as many prize draws than those in the Usual CM for alcohol abstinence during weeks 5-20, plus treatment as usual.

Find a Location

Who is running the clinical trial?

Washington State UniversityLead Sponsor
104 Previous Clinical Trials
57,523 Total Patients Enrolled
8 Trials studying Alcoholism
1,216 Patients Enrolled for Alcoholism
National Institute on Alcohol Abuse and Alcoholism (NIAAA)NIH
815 Previous Clinical Trials
1,159,471 Total Patients Enrolled
428 Trials studying Alcoholism
777,899 Patients Enrolled for Alcoholism
Michael G McDonell, PhDPrincipal InvestigatorWashington State University
1 Previous Clinical Trials
17 Total Patients Enrolled
1 Trials studying Alcoholism
17 Patients Enrolled for Alcoholism

Media Library

High-Magnitude CM Clinical Trial Eligibility Overview. Trial Name: NCT03481049 — N/A
Alcoholism Research Study Groups: Usual CM, High-Magnitude CM, Shaping CM
Alcoholism Clinical Trial 2023: High-Magnitude CM Highlights & Side Effects. Trial Name: NCT03481049 — N/A
High-Magnitude CM 2023 Treatment Timeline for Medical Study. Trial Name: NCT03481049 — N/A
~56 spots leftby Jul 2025