Browse 2 Diabetes Insipidus Medical Studies Across 3 Cities
3 Diabetes Insipidus Clinics
What Are Diabetes Insipidus Clinical Trials?
Diabetes Insipidus (DI) is a rare condition that causes excessive urination. Di occurs when the kidney is unable to conserve water through reabsorption. While a healthy adult typically urinates around 2.8 liters a day, a patient suffering from diabetes insipidus would excrete almost 19 liters.
Diabetes insipidus is caused due to a problem with the antidiuretic hormone (ADH), also called vasopressin, which controls the amount of water retained by the kidney. Diabetes insipidus is divided into four types:
Diabetes Insipidus clinical trials involve research studies on the etiology and possible risk factors of all four types of the condition. Moreover, clinical trials are being conducted to develop improved diagnostic measures to target the underlying cause, as treatment varies depending on the type of diabetes insipidus.
Why is Diabetes Insipidus Being Studied through Clinical Trials?
According to the National Institute of Diabetes and Digestive and Kidney Diseases, diabetes insipidus is a sporadic disease that affects one in 25,000 people worldwide. While rare, the condition can lead to excessive water loss and dehydration, especially in children. Dehydration leads to dry mouth, fatigue, dizziness, and dry skin. Moreover, DI causes an electrolyte imbalance in the boy resulting in nausea, weakness, muscle cramps, and more.
Current treatment methods include lifestyle changes or medication such as desmopressin. However, desmopressin can have severe side effects, including headaches, nosebleeds, and abdominal pain. Moreover, the proper treatment varies depending on the type of diabetes insipidus, but current diagnostic methods cannot accurately judge the cause.
Therefore, diabetes insipidus clinical trials are being conducted to develop improved treatment and diagnostic methods for reduced side effects and better identify the condition to prevent progression and complications.
What Are The Types of Treatment Available For Diabetes Insipidus?
Current treatment methods depend on the type of diabetes insipidus.
What Are Some Recent Breakthrough Clinical Trials for Diabetes Insipidus?
Current diabetes insipidus clinical trials are centered around drug therapy and improved diagnostic methods to treat the disease early on to avoid complications. Some of the recent breakthrough clinical trials for diabetes insipidus include:
2022: a phase 2 clinical study (NCT05190744) by Mayo Clinic to study the efficacy and safety of medication B in treated diabetes insipidus as an inherited condition or one acquired from lithium treatment.
2022: a phase 2 clinical trial (NCT04789148) by Elizabeth Austen Lawson to study the effects of oxytocin that is administered nasally (4 IU and 24 IU)in treating central diabetes insipidus