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Behavioural Intervention

Cognitive Rehabilitation for Long COVID

N/A

Waitlist Available

Research Sponsored by Duke University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline, eoi (day 70), eos (day 160)

Awards & highlights

Study Summary

This trial seeks to evaluate interventions to improve cognitive symptoms caused by PASC. It includes a commercially available program (BrainHQ) plus potential other interventions that could improve cognition.

Who is the study for?

This trial is for individuals with Long COVID who experience cognitive issues like trouble with thinking or attention. Participants must meet the broader RECOVER-NEURO protocol criteria and cannot have metal objects in their head/neck, skin conditions near tDCS stimulation sites, or any other risks as determined by the investigator.Check my eligibility

What is being tested?

The study tests BrainHQ exercises alone, combined with PASC CoRE (a cognitive rehabilitation program), or paired with active/sham tDCS (transcranial direct current stimulation) to see if they improve cognition in Long COVID patients compared to standard activities.See study design

What are the potential side effects?

Potential side effects may include discomfort at the electrode site from tDCS, mild headaches, itching under electrode pads during stimulation, and fatigue. Side effects are generally minimal for BrainHQ exercises.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline, eoi (day 70), eos (day 160)

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline, eoi (day 70), eos (day 160)

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, eoi (day 70), eos (day 160) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Secondary outcome measures

Change in Everyday Cognition 2 (ECog2)

Change in PROMIS-cognitive function - short form 8a (PROMIS-Cog) total score

Change on an objective neurocognitive battery scores

+1 more

Trial Design

5Treatment groups

Experimental Treatment

Active Control

Placebo Group

Group I: BrainHQ + PASC CoREExperimental Treatment2 Interventions

BrainHQ plus 9 group sessions at 1.5 hr/session and 3 individual sessions at 1 hr/session

Group II: BrainHQExperimental Treatment1 Intervention

5 sessions/week at 30 min/session

Group III: Brain HQ + tDCS-activeExperimental Treatment2 Interventions

2.0 mA stimulation delivered for 30 min during each BrainHQ session

Group IV: BrainHQ Active ComparatorActive Control1 Intervention

5 sessions/week at 30 min/session

Group V: Brain HQ + tDCS-shamPlacebo Group2 Interventions

Inactive stimulation delivered for 30 min during each BrainHQ session

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Duke UniversityLead Sponsor

2,359 Previous Clinical Trials

3,419,907 Total Patients Enrolled

Daniel Laskowitz, MD MHSStudy ChairDuke University

1 Previous Clinical Trials

315 Total Patients Enrolled

Kanecia Zimmerman, MD PhDStudy ChairDuke University

2 Previous Clinical Trials

1,215 Total Patients Enrolled

Media Library

BrainHQ (Behavioural Intervention) Clinical Trial Eligibility Overview. Trial Name: NCT05965739 — N/A

Long COVID Syndrome Research Study Groups: Brain HQ + tDCS-sham, BrainHQ, BrainHQ + PASC CoRE, Brain HQ + tDCS-active, BrainHQ Active Comparator

Long COVID Syndrome Clinical Trial 2023: BrainHQ Highlights & Side Effects. Trial Name: NCT05965739 — N/A

BrainHQ (Behavioural Intervention) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05965739 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is enrollment in this trial currently open?

"The clinicaltrials.gov page for this trial states that it is no longer actively recruiting patients, having been first posted on August 1st 2023 and last updated the same day. However, there are currently 581 other research studies which require volunteers."

Answered by AI

Who else is applying?

What site did they apply to?

All sites listed under NCT05965752

What portion of applicants met pre-screening criteria?

Met criteria

How many prior treatments have patients received?

Why did patients apply to this trial?

It's been a little over a year since I had COVID-19 (confirmed PCR). Since then, I have been suffering from multiple issues including brain fog, headaches, dizziness, sleep difficulties, anxiety and depression.

PatientReceived 1 prior treatment

Recent research and studies

clinicaltrials.govStudy

RECOVER-NEURO: Platform Protocol, Appendix_A to Measure the Effects of BrainHQ, PASC CoRE and tDCS Interventions on Long COVID Symptoms

2023. "RECOVER-NEURO: Platform Protocol, Appendix_A to Measure the Effects of BrainHQ, PASC CoRE and tDCS Interventions on Long COVID Symptoms". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05965739.

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