Transcranial Direct Current Simulation for Aging

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
North Florida/South Georgia Veterans Health System, Gainesville, FL, Gainesville, FL
Aging
Experimental: Locomotor Learning - Behavioral
Eligibility
65+
All Sexes
What conditions do you have?
Select

Study Summary

Older adults and stroke survivors often have difficulty performing complex walking tasks, due in part to changes in the brain. One task often overlooked is turning, which can lead to injury when performed poorly. The investigators will use non-invasive brain stimulation to assess brain activity and relate those observations to turning performance in older adults and stroke survivors.

Treatment Effectiveness

Study Objectives

5 Primary · 1 Secondary · Reporting Duration: 5 minutes, Measured two times approximately 3 weeks apart

20 minutes, Measured at Baseline
Resting Motor Threshold (percent of machine output)
30 minutes, Measured at Baseline
Duration of Cortical Silent Period (CSP) (ms)
Ratio of motor evoked potential amplitudes (no units)
5 minutes
Katz Independence Questionnaire
Week 3
180 Degree Turn Duration
360 degree Turn Duration

Trial Safety

Trial Design

2 Treatment Groups

Transcranial Direct Current Simulation
1 of 2
Sham Stimulation
1 of 2
Experimental Treatment
Non-Treatment Group

50 Total Participants · 2 Treatment Groups

Primary Treatment: Transcranial Direct Current Simulation · Has Placebo Group · N/A

Transcranial Direct Current Simulation
Behavioral
Experimental Group · 1 Intervention: Experimental: Locomotor Learning · Intervention Types: Behavioral
Sham Stimulation
Behavioral
ShamComparator Group · 1 Intervention: Experimental: Locomotor Learning · Intervention Types: Behavioral

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 5 minutes, measured two times approximately 3 weeks apart
Closest Location: North Florida/South Georgia Veterans Health System, Gainesville, FL · Gainesville, FL
Photo of Gainesville  1Photo of Gainesville  2
2009First Recorded Clinical Trial
4 TrialsResearching Aging
36 CompletedClinical Trials

Eligibility Criteria

Age 65+ · All Participants · 4 Total Inclusion Criteria

Mark “yes” if the following statements are true for you:
You have a high risk of breast cancer if you are older than 65 years.
Self-report of some difficulty with walking tasks.
You are willing to be randomized to either study group and to participate in all aspects of study assessment and intervention.

About The Reviewer

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 9th, 2021

Last Reviewed: August 12th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.