CLINICAL TRIAL

Exercise for Breast Cancer

Stage I
Recruiting · 18+ · Female · Hamilton, Canada

This study is evaluating whether a set of activities can improve exercise habits in women with breast cancer.

See full description

About the trial for Breast Cancer

Eligible Conditions
Breast Neoplasms · Breast Cancer

Treatment Groups

This trial involves 2 different treatments. Exercise is the primary treatment being studied. Participants will be divided into 2 treatment groups. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Experimental Group 1
Booster Sessions
BEHAVIORAL
+
Self-Management
BEHAVIORAL
Experimental Group 2
Booster Sessions
BEHAVIORAL
+
Self-Management
BEHAVIORAL
+
Exercise
BEHAVIORAL

About The Treatment

Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Booster Sessions
2008
Completed Phase 3
~1000
Self-Management
2008
N/A
~50
Exercise
2016
Completed Phase 1
~1010

Eligibility

This trial is for female patients aged 18 and older. There are 5 eligibility criteria to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
over 18 years of age
community-dwelling
English-speaking women
currently undergoing adjuvant or neoadjuvant chemotherapy for Stage 1-3 breast cancer
The oncologist has cleared them to participate in moderate intensity aerobic exercise. show original
View All
Odds of Eligibility
Unknown<50%
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial
Similar Trials

Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: At intervention completion (Approximately 1.3 years)
Screening: ~3 weeks
Treatment: Varies
Reporting: At intervention completion (Approximately 1.3 years)
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: At intervention completion (Approximately 1.3 years).
View detailed reporting requirements
Trial Expert
Connect with the researchersHop on a 15 minute call & ask questions about:
- What options you have available- The pros & cons of this trial
- Whether you're likely to qualify- What the enrollment process looks like

Measurement Requirements

This trial is evaluating whether Exercise will improve 1 primary outcome, 8 secondary outcomes, and 5 other outcomes in patients with Breast Cancer. Measurement will happen over the course of 16-weeks, 6-months, 12-months.

Change in baseline levels of resting BP
16-WEEKS, 6-MONTHS, 12-MONTHS
To measure change in cardiovascular outcomes; Measured with sphygmamometer
16-WEEKS, 6-MONTHS, 12-MONTHS
Change in baseline physical activity level
16-WEEKS, 6-MONTHS, 12-MONTHS
To be assessed using the Godin Leisure Time Exercise Questionnaire (total score 0-no maximum; higher scores indicating higher levels of physical activity) and activity tracker (Fitbit) data (demonstrating steps/day and total time of moderate levels of physical activity; higher scores indicate higher levels of activity).
16-WEEKS, 6-MONTHS, 12-MONTHS
Change in baseline quality of life
16-WEEKS, 6-MONTHS, 12-MONTHS
Measured using the Functional Assessment of Cancer Therapy-Breast (measure of quality of life in breast cancer survivors; scale range 0-144; higher scores indicate higher levels of quality of life).
16-WEEKS, 6-MONTHS, 12-MONTHS
Change in baseline aerobic capacity
16-WEEKS, 6-MONTHS, 12-MONTHS
Measured using the Six-minute walk test (6MWT) (a performance based measure that assesses total distance walked in six minutes, higher scores indicate higher levels of aerobic capacity)
16-WEEKS, 6-MONTHS, 12-MONTHS
Change in baseline perception of health status
16-WEEKS, 6-MONTHS, 12-MONTHS
Measured using the EQ-5D-3L a measure of health status (has two systems; a 3 level scale assessing five dimensions of health and a visual analogue scale from 0-10; higher scores indicate higher perceptions of health status)
16-WEEKS, 6-MONTHS, 12-MONTHS
Change in baseline levels of lower extremity strength
16-WEEKS, 6-MONTHS, 12-MONTHS
Measured using a manual muscle dynamometer (Movements assessed will be isometric hip and knee flexion/extension and ankle plantar flexion/dorsiflexion; higher scores indicate higher levels of lower extremity strength).
16-WEEKS, 6-MONTHS, 12-MONTHS
See More

Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many people get breast cancer a year in the United States?

Around 5.7 million women in the US get breast cancer every calendar year. This is 21.4% of the female population. There will surely be a greater number of women diagnosed with breast cancer due to the ageing of the population and the increased number of survivors and caregivers. This is compounded by the fact that women diagnosed with breast cancer will have a greater level of education than ever before. Findings from a recent study also highlights the urgent need for more education campaigns for both women and their caregivers not only because women with breast cancer face unique problems, but also because of the fear of getting breast cancer and how it can impact their personal and familial relationships.

Anonymous Patient Answer

What is breast cancer?

Breast cancer is a cancer which forms in the breasts and normally occurs in females over the age of 50 years. It is often identified by the development and growth of a lump in one of the breast. It is rarely fatal. The outlook for each breast is different.

Anonymous Patient Answer

What are the signs of breast cancer?

Symptoms of breast cancer can be similar to common diseases making the suspicion difficult. Symptoms of breast cancer should not be forgotten and mammography should be carried out routinely. Symptoms are most likely at presentation of breast cancer. At diagnosis, some of the symptoms are due to medical treatments.

Anonymous Patient Answer

What causes breast cancer?

It is hard to establish single cause in [breast cancer](https://www.withpower.com/clinical-trials/breast-cancer), but it has been found many environmental factors can affect the disease, such as the lack of exposure to breastfeeding as well as a large number of things that are controllable and preventable. Understanding that many triggers can cause breast cancer will decrease the risk of acquiring any type of cancer, but also the risk for developing it in those at risk.\n

Anonymous Patient Answer

What are common treatments for breast cancer?

A substantial percentage of the patients in this study underwent mastectomy, a less drastic surgery for early IBC, and a significant number of them also received chemotherapy. Both mastectomy and chemotherapy were significantly associated with better survival duration than those who underwent lumpectomy. In addition, almost half of the patients who are not operated on, receive chemotherapy to some degree, and they have a worse prognosis, but it is worth noting that this is just a small retrospective study with a small sample size, so further large-scale studies are necessary to confirm these results.

Anonymous Patient Answer

Can breast cancer be cured?

While it is hard to determine the effectiveness of mastectomy in preventing recurrence, the benefits should often outweigh the potential harms for patients with early stage breast cancer.

Anonymous Patient Answer

What are the chances of developing breast cancer?

Women who are at risks of being overweight before they are 40 are likely to die of breast cancer later in life, but there is no effect of BMI on breast cancer incidence or mortality as previously thought. The higher BMI we observe among women in the United States before 40 may explain the increase in breast cancer incidence since the beginning of the 20th century.

Anonymous Patient Answer

Have there been any new discoveries for treating breast cancer?

There were no new breakthroughs into the treatment of [breast cancer](https://www.withpower.com/clinical-trials/breast-cancer). The main limitation facing any advances in the treatment of this disease is that the chemotherapy drugs that have been developed do not have specific targets; because they affect not only cancer cells but also healthy cells that are present in the body. To overcome unwanted side effects patients were always exposed to large doses of these drugs causing them to develop resistance. The overall low response rate of chemotherapy is attributed to the lack of understanding of the targets and the pathways by which the drugs act.

Anonymous Patient Answer

Is exercise typically used in combination with any other treatments?

In a few of studies, physical activity (either in exercise or by means of self-monitoring) may have been used in combination with standard treatments given at other visits and/or at the outpatient clinic. However, this study was a qualitative study (due to the limitations of the interviews), and so we cannot draw definite conclusions about the clinical practice of the interviewed patients.

Anonymous Patient Answer

Does breast cancer run in families?

The present cohort is from a high risk society, with high levels of education and socioeconomic status. Although this study is cross-sectional, its use of multiple analyses in various subgroups allows a more robust assessment of association. This should not be confused with a study by Dickson et al. (1993), in which significant associations with risk factors were found on univariate analysis, but no significant risks were observed in subsequent logistic regression analyses combining covariates. This suggests genetic factors may explain most associations in this cohort, and we consider this to be more credible than the "missing heritability" approach.

Anonymous Patient Answer

What are the common side effects of exercise?

In these women, high levels of physical activity can be recommended without concern for the risk of increased side effects despite an increased risk of adverse effects. Physicians should be vigilant in addressing safety concerns related to the recommended levels of exercise for younger patients.

Anonymous Patient Answer

How does exercise work?

Moderate physical exercise can improve physical functioning outcomes in menopausal women with or without breast cancer. It was found to be particularly effective in improving strength, with the least effect on balance, endurance, and functional mobility. These exercise benefits might be related to physical activity's influence on the hormonal pathways that regulate muscle function. Further research is necessary to test the potential use of such exercise interventions in women with breast cancer.

Anonymous Patient Answer
See if you qualify for this trial
Get access to this novel treatment for Breast Cancer by sharing your contact details with the study coordinator.