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Prone Positioning (PP) for Hypoxemic Respiratory Failure (CORONA Trial)

N/A
Waitlist Available
Led By Jason Weatherald, MD
Research Sponsored by University of Calgary
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 90 days
Awards & highlights

CORONA Trial Summary

This trial will test whether lying face-down can improve outcomes for hospitalized patients with breathing problems due to COVID-19, who are not candidates for mechanical ventilation.

Eligible Conditions
  • Hypoxemic Respiratory Failure
  • COVID-19
  • Acute Respiratory Distress Syndrome
  • Coronavirus

CORONA Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~90 days
This trial's timeline: 3 weeks for screening, Varies for treatment, and 90 days for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Hospital mortality or discharge to hospice
Secondary outcome measures
Admission to ICU
Adverse Events and Serious Adverse Events
Change in SpO2
+6 more

CORONA Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Prone Positioning (PP)Experimental Treatment1 Intervention
The intervention for this study is PP. Patients at participating sites allocated to the intervention arm of the study will be prompted by ward nurses and respiratory therapists to assume and maintain a prone position for varying durations, four times per day.
Group II: Control - usual managementActive Control1 Intervention
The control group will consist of standard medical care with no instructions or prompts to change positioning to staff or patients.

Find a Location

Who is running the clinical trial?

University of CalgaryLead Sponsor
791 Previous Clinical Trials
868,138 Total Patients Enrolled
2 Trials studying Hypoxemic Respiratory Failure
20,836 Patients Enrolled for Hypoxemic Respiratory Failure
Alberta Health servicesOTHER
157 Previous Clinical Trials
648,948 Total Patients Enrolled
2 Trials studying Hypoxemic Respiratory Failure
20,836 Patients Enrolled for Hypoxemic Respiratory Failure
Jason Weatherald, MDPrincipal InvestigatorUniversity of Calgary
1 Previous Clinical Trials

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
CORONA (COvid pRONe hypoxemiA): Prone Positioning for Hypoxemic COVID-19 Patients With Do-not-intubate Goals
Ken Kuljit Parhar, MD 2020. "CORONA (COvid pRONe hypoxemiA): Prone Positioning for Hypoxemic COVID-19 Patients With Do-not-intubate Goals". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04402879.
All > Covid
~135 spots leftby Apr 2025
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