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Steroid/Anesthesia Mixture for Neurogenic Cough

Phase 4
Waitlist Available
Led By Benjamin Rubinstein, MD
Research Sponsored by Eastern Virginia Medical School
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Previously or Newly Diagnosed Chronic Neurogenic Cough
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up pretreatment, 30 minutes post treatment, 1 week post treatment, 6 weeks post treatment
Awards & highlights

Study Summary

This trial is testing if blocking the nerve that causes chronic neurogenic cough with an injection of local anesthetic/steroid mixture can help the cough.

Eligible Conditions
  • Chronic Neurogenic Cough
  • Laryngeal Nerve Block
  • Laryngospasm

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
You have been diagnosed with long-lasting cough caused by a neurological condition.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~pretreatment, 30 minutes post treatment, 1 week post treatment, 6 weeks post treatment
This trial's timeline: 3 weeks for screening, Varies for treatment, and pretreatment, 30 minutes post treatment, 1 week post treatment, 6 weeks post treatment for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Intervention vs. Placebo in Neurogenic Cough using Capsaicin Challenge
Secondary outcome measures
Intervention vs. Placebo in Neurogenic Cough using the Central Sensitization Inventory
Intervention vs. Placebo in Neurogenic Cough using the Newcastle Laryngeal Hypersensitivity Questionnaire
Intervention vs. Placebo in Neurogenic Cough using the Urge to Cough Scale
+1 more

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Intervention (Steroid/Anesthetic Mixture)Experimental Treatment1 Intervention
The steroid/anesthetic mixture will be injected via a 27-gauge needle once at the baseline or during the 6-week crossover timepoint.
Group II: Placebo (Normal Saline)Placebo Group1 Intervention
The placebo (Normal Saline) will be injected via a 27-gauge needle once at the baseline or during the 6-week crossover timepoint.

Find a Location

Who is running the clinical trial?

Eastern Virginia Medical SchoolLead Sponsor
68 Previous Clinical Trials
10,358 Total Patients Enrolled
Benjamin Rubinstein, MDPrincipal InvestigatorEastern Virginia Medical School Department of Otolaryngology - Head and Neck Surgery
1 Previous Clinical Trials
10 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are new participants being accepted into this research project?

"Affirmative. The clinical trial is actively recruiting patients, as evidenced by the information on clinicaltrials.gov which indicates that it was posted on July 21st 2021 and updated last March 14th 2022. It requires 40 participants from a single medical centre for enrollment."

Answered by AI

What is the participant count of this research endeavor?

"Affirmative. The information sourced from clinicaltrials.gov reveals that this medical trial, first posted on July 21st 2021, is actively accepting patients. 40 participants must be recruited at the sole location of the study."

Answered by AI

What potential risks do patients incur when exposed to the Steroid/Anesthesia Mixture?

"We rate the safety of Steroid/Anesthesia Mixture a 3, as it has been approved and entered Phase 4 clinical trials."

Answered by AI

Who else is applying?

What state do they live in?
North Carolina
How old are they?
18 - 65
What site did they apply to?
Eastern Virginia Medical School Ear, Nose, and Throat Surgeons
What portion of applicants met pre-screening criteria?
Met criteria
~11 spots leftby Mar 2025