Steroid/Anesthesia Mixture for Chronic Neurogenic Cough

Phase-Based Progress Estimates
3
Effectiveness
3
Safety
Eastern Virginia Medical School Ear, Nose, and Throat Surgeons, Norfolk, VAChronic Neurogenic Cough+2 MoreSteroid/Anesthesia Mixture - Drug
Eligibility
18+
All Sexes
What conditions do you have?
Select

Study Summary

This trial is testing if blocking the nerve that causes chronic neurogenic cough with an injection of local anesthetic/steroid mixture can help the cough.

Eligible Conditions
  • Chronic Neurogenic Cough
  • Laryngospasm
  • Laryngeal Nerve Block

Treatment Effectiveness

Effectiveness Progress

3 of 3
This is further along than 93% of similar trials

Study Objectives

1 Primary · 4 Secondary · Reporting Duration: Pretreatment, 30 minutes post treatment, 1 week post treatment, 6 weeks post treatment

Week 6
Intervention vs. Placebo in Neurogenic Cough using Capsaicin Challenge
Week 6
Quality of Life Measurements
Week 6
Intervention vs. Placebo in Neurogenic Cough using the Central Sensitization Inventory
Intervention vs. Placebo in Neurogenic Cough using the Newcastle Laryngeal Hypersensitivity Questionnaire
Intervention vs. Placebo in Neurogenic Cough using the Urge to Cough Scale

Trial Safety

Safety Progress

3 of 3
This is further along than 85% of similar trials

Trial Design

2 Treatment Groups

Intervention (Steroid/Anesthetic Mixture)
1 of 2
Placebo (Normal Saline)
1 of 2

Experimental Treatment

Non-Treatment Group

40 Total Participants · 2 Treatment Groups

Primary Treatment: Steroid/Anesthesia Mixture · Has Placebo Group · Phase 4

Intervention (Steroid/Anesthetic Mixture)
Drug
Experimental Group · 1 Intervention: Steroid/Anesthesia Mixture · Intervention Types: Drug
Placebo (Normal Saline)
Drug
PlaceboComparator Group · 1 Intervention: Placebo · Intervention Types: Drug

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: pretreatment, 30 minutes post treatment, 1 week post treatment, 6 weeks post treatment

Who is running the clinical trial?

Eastern Virginia Medical SchoolLead Sponsor
65 Previous Clinical Trials
10,253 Total Patients Enrolled
Benjamin Rubinstein, MDPrincipal InvestigatorEastern Virginia Medical School Department of Otolaryngology - Head and Neck Surgery
1 Previous Clinical Trials
10 Total Patients Enrolled

Eligibility Criteria

Age 18+ · All Participants · 2 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
You have been diagnosed with long-lasting cough caused by a neurological condition.

Who else is applying?

What state do they live in?
North Carolina100.0%
How old are they?
18 - 65100.0%
What site did they apply to?
Eastern Virginia Medical School Ear, Nose, and Throat Surgeons100.0%
What portion of applicants met pre-screening criteria?
Met criteria100.0%

Frequently Asked Questions

Are new participants being accepted into this research project?

"Affirmative. The clinical trial is actively recruiting patients, as evidenced by the information on clinicaltrials.gov which indicates that it was posted on July 21st 2021 and updated last March 14th 2022. It requires 40 participants from a single medical centre for enrollment." - Anonymous Online Contributor

Unverified Answer

What is the participant count of this research endeavor?

"Affirmative. The information sourced from clinicaltrials.gov reveals that this medical trial, first posted on July 21st 2021, is actively accepting patients. 40 participants must be recruited at the sole location of the study." - Anonymous Online Contributor

Unverified Answer

What potential risks do patients incur when exposed to the Steroid/Anesthesia Mixture?

"We rate the safety of Steroid/Anesthesia Mixture a 3, as it has been approved and entered Phase 4 clinical trials." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.