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Anticonvulsant Agent

Perampanel for Low Grade Glioma

Q: What therapeutic applications is Perampanel employed for?

<p>Perampanel is a popular choice to alleviate <a href="https://www.withpower.com/clinical-trials/anxiety">anxiety</a>. It can also help with partial seizures that secondary generalize, and those struggling with restless leg syndrome (RLS).</p>

Phase 4

Waitlist Available

Led By William Tatum

Research Sponsored by Mayo Clinic

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up at 3 months

Awards & highlights

Study Summary

This trial studies the side effects of perampanel and how well it works in reducing seizure frequency in patients with high-grade glioma and focal epilepsy.

Eligible Conditions

Low Grade Glioma
Gliomas
Epilepsy
Malignant Glioma

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ at 3 months

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~at 3 months

This trial's timeline: 3 weeks for screening, Varies for treatment, and at 3 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Decline in Neuropsychological Function

Number of Participants Alive at 3 Months With High-grade Glioma Treated With PER

Number of Patients With a High-grade Glioma Who Achieve a > 50% Reduction in Focal Seizures With PER 4 mg Daily After Failing 1 or More ASDs

+1 more

Side effects data

From 2021 Phase 4 trial • 54 Patients • NCT03288129

28%

Dizziness

17%

Fatigue

15%

Somnolence

11%

Vomiting

Nasopharyngitis

Irritability

Headache

Nausea

Ear infection

Upper respiratory tract infection

Balance disorder

Memory impairment

Aggression

Depression

Oropharyngeal pain

Mental status changes

Sudden unexplained death in epilepsy

Transient ischaemic attack

Suicidal ideation

100%

80%

60%

40%

20%

Study treatment Arm

Perampanel 12 mg

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: Arm A (perampanel)Experimental Treatment3 Interventions

Patients receive perampanel PO QD for 40 weeks in the absence of disease progression or unacceptable toxicity.

Group II: Arm B (ASD)Active Control3 Interventions

Patients receive ASD per standard of care for 40 weeks in the absence of disease progression or unacceptable toxicity.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Perampanel

2014

Completed Phase 4

~2890

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Mayo ClinicLead Sponsor

3,205 Previous Clinical Trials

3,766,780 Total Patients Enrolled

National Cancer Institute (NCI)NIH

13,654 Previous Clinical Trials

40,933,149 Total Patients Enrolled

William TatumPrincipal InvestigatorMayo Clinic

1 Previous Clinical Trials

20 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How extensive is the participant pool for this experiment?

"Affirmative. As per the information available on clinicaltrials.gov, this medical trial is in the process of recruiting patients with a start date of April 30th 2020 and most recent update being November 22nd 2021. The study requires 40 participants to be enrolled at one site."

Answered by AI

Are there any opportunities for recruitment of participants in this medical experiment?

"Affirmative. According to the clinicaltrials.gov listing, this trial is currently enrolling participants that were first posted on April 30th 2020 and last updated November 22nd 2021. The research requires 40 patients from a single medical site."

Answered by AI

What therapeutic applications is Perampanel employed for?

"Perampanel is a popular choice to alleviate anxiety. It can also help with partial seizures that secondary generalize, and those struggling with restless leg syndrome (RLS)."

Answered by AI

To what extent does Perampanel present a risk to individuals?

"Our assessment of the safety profile for Perampanel ranks it a 3, as this medication has already been validated in Phase 4 trials and approved for public use."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Perampanel for the Reduction of Seizure Frequency in Patients With High-grade Glioma and Focal Epilepsy

William Tatum, DO 2020. "Perampanel for the Reduction of Seizure Frequency in Patients With High-grade Glioma and Focal Epilepsy". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04650204.