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Local Anesthetic
Single Quadratus Lumborum Nerve Block for Postoperative Pain
Phase 4
Waitlist Available
Led By Jacques E Chelly, MD, PhD, MBA
Research Sponsored by Jeremy Kearns
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 72 hours after surgery
Awards & highlights
Study Summary
This trial is comparing the efficacy of two different types of pain management for people undergoing surgery - continuous nerve block vs. single nerve block with IV lidocaine infusion.
Eligible Conditions
- Postoperative Pain
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 72 hours after surgery
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~72 hours after surgery
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Secondary outcome measures
Incidence of Adverse Events
Local Anesthetic Consumption After Surgery
Opioid Consumption After Surgery
+3 moreTrial Design
2Treatment groups
Experimental Treatment
Active Control
Group I: Single nerve blocks plus IV lidocaine infusionExperimental Treatment6 Interventions
A total of 30 subjects equally distributed to either Erector Spinae Plane block for unilateral thoracic surgery, or Quadratus Lumborum block for major abdominal surgery, will be included . Patients in this group will receive 20ml 0.5% ropivacaine, 4mg dexamethasone, and 20mcg dexmedetomidine (30mcg if only one block is performed) per block after proper positioning of the Tuohy needle. Upon patient arrival in the recovery room a continuous infusion of IV lidocaine 50 mg /hr will be started and continued for 72 hours or until 12 hours prior to patient discharge, whichever comes first, which is standard of care at this institution.
Group II: Continuous nerve blocksActive Control4 Interventions
A total of 30 subjects equally distributed to either continuous Erector Spinae Plane block for unilateral thoracic surgery , or continuous Quadratus Lumborum block for major abdominal surgery. Patients in this group will receive 20ml 0.5% ropivacaine per block performed after positioning of the needle followed by continuous perineural infusion of 0.25% lidocaine (10ml/hr) beginning in the post-anesthesia care unit (PACU) and continued for 72 hours or until 12 hours prior to patient discharge, whichever comes first, which is standard of care at this institution.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Lidocaine
FDA approved
Ropivacaine
FDA approved
Dexamethasone
FDA approved
Dexmedetomidine
FDA approved
Find a Location
Who is running the clinical trial?
Jeremy KearnsLead Sponsor
Jacques E. ChellyLead Sponsor
8 Previous Clinical Trials
629 Total Patients Enrolled
1 Trials studying Postoperative Pain
68 Patients Enrolled for Postoperative Pain
Jacques E Chelly, MD, PhD, MBAPrincipal InvestigatorUniversity of Pittsburgh Medical Center
2 Previous Clinical Trials
327 Total Patients Enrolled
1 Trials studying Postoperative Pain
41 Patients Enrolled for Postoperative Pain
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