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GLP-1 Receptor Agonist

Liraglutide for Insulin Resistance

Phase 4
Waitlist Available
Led By Peter D Reaven, MD
Research Sponsored by Phoenix VA Health Care System
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 3 weeks
Awards & highlights

Summary

In this research study, investigators will test the effects of an approved medication for diabetes,Liraglutide, to reduce insulin resistance that develops from eating a diet high in saturated fats.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~3 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 3 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Whole Body Insulin Sensitivity (insulin suppression test)
Secondary outcome measures
Adipose tissue arteriole function (vasodilation measurement)
Adipose tissue inflammation measures (e.g., interleukin (IL)-6, and -8, adiponectin, TNF-alpha, nuclear factor-kappa b, gene and protein expression)
Changes in adipose tissue insulin signaling pathway activation (compare insulin signaling pathway activity (e.g., Akt and insulin receptor phosphorylation)
+6 more

Side effects data

From 2017 Phase 4 trial • 100 Patients • NCT02014740
29%
nausea
100%
80%
60%
40%
20%
0%
Study treatment Arm
Liraglutide
Metformin

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: LiraglutideExperimental Treatment1 Intervention
Liraglutide titration up to 1.8 mg/d over approximately 3 weeks
Group II: Sugar pillPlacebo Group1 Intervention
matching placebo and titration
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Liraglutide
FDA approved

Find a Location

Who is running the clinical trial?

Phoenix VA Health Care SystemLead Sponsor
12 Previous Clinical Trials
1,440 Total Patients Enrolled
1 Trials studying Insulin Resistance
300 Patients Enrolled for Insulin Resistance
Novo Nordisk A/SIndustry Sponsor
1,525 Previous Clinical Trials
2,419,701 Total Patients Enrolled
4 Trials studying Insulin Resistance
127 Patients Enrolled for Insulin Resistance
Peter D Reaven, MDPrincipal InvestigatorCarl T. Hayden Medical Research Foundation
5 Previous Clinical Trials
1,634 Total Patients Enrolled
1 Trials studying Insulin Resistance
300 Patients Enrolled for Insulin Resistance
~3 spots leftby Jul 2025
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