← Back to Search

Vitamin

Vitamin A for Olfactory Disorders

N/A

Waitlist Available

Led By Amin Javer, MD FRCSCFARS

Research Sponsored by St. Paul's Hospital, Canada

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Patients 19 years and above diagnosed with loss of olfactory function, (with or without history of sinonasal surgery) currently receiving sinonasal-related care at the St Paul's Sinus Centre.

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up for each subject this test will take between 5-10 minutes.

Awards & highlights

Study Summary

This trial will examine the effects of topical application of vitamin A on olfactory function in patients with olfactory loss.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ for each subject this test will take between 5-10 minutes.

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~for each subject this test will take between 5-10 minutes.

This trial's timeline: 3 weeks for screening, Varies for treatment, and for each subject this test will take between 5-10 minutes. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Olfactory Tests.

Secondary outcome measures

Questionnaire of Olfactory Disorders

Sinonasal Outcomes Test - 22 (SNOT-22)

Sinus Mucosal Inflammation - Philpott-Javer (PJ) and Modified Lund-Kennedy (MLK) Endoscopic Staging System (ESS)

Trial Design

3Treatment groups

Experimental Treatment

Active Control

Group I: B: Vitamin AExperimental Treatment1 Intervention

Group B: This study group will receive Vitamin A in addition to their standard of care. They will not receive olfactory retraining.

Group II: A: Vitamin A and Olfactory RetrainingExperimental Treatment1 Intervention

Group A: This study group will receive intranasal vitamin A at 10,000 I.U. per day and olfactory retraining using scented oils in addition to their standard of care.

Group III: C: Standard of CareActive Control1 Intervention

Group C: This study group will receive only standard of care .

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Vitamin A

2006

Completed Phase 4

~72300

0 / 1Eligibility criteria met

Find a Location

Who is running the clinical trial?

St. Paul's Hospital, CanadaLead Sponsor

44 Previous Clinical Trials

12,600 Total Patients Enrolled

Amin Javer, MD FRCSCFARSPrincipal InvestigatorUniversity of British Columbia

1 Previous Clinical Trials

130 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the requirements to partake in this experiment?

"This trial is recruiting 120 participants suffering from smell-related disorders who are between the ages of 19 and 90. To be considered, patients must meet a few key requirements: Over 19 years old with olfactory dysfunction (with or without prior sinonasal surgery) currently under care at St Paul's Sinus Centre."

Answered by AI

How many people are involved in the experiment?

"Affirmative. The information located on clinicaltrials.gov shows that this medical trial is presently seeking participants, which was initially made available on May 25th 2016 and recently updated on September 18th 2019. This experiment is trying to enroll 120 patients from 2 separate sites."

Answered by AI

Is this experiment open to participants who are over 25 years of age?

"This experiment seeks individuals over 19 years old and under 90 to participate."

Answered by AI

Is enrollment into this trial currently feasible for participants?

"As exhibited on clinicaltrials.gov, this trial is presently enlisting participants. The original post date was May 25th 2016 and the most recently revised information is from September 18th 2019."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Intranasal Retinoic Acid Treatment for Patients With OlfactoryLOSS: A RANDOMIZED CONTROLLED TRIAL

Amin Javer 2016. "Intranasal Retinoic Acid Treatment for Patients With OlfactoryLOSS: A RANDOMIZED CONTROLLED TRIAL". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03574701.