Study Summary
This trial will study how well ruxolitinib cream works to treat vitiligo by measuring changes in biomarkers.
Treatment Effectiveness
Effectiveness Progress
Study Objectives
1 Primary · 2 Secondary · Reporting Duration: 56 weeks
56 weeks
Number of treatment emergency Adverse Events
Week 24
Correlation of CXCL10 biomarker to Vitiligo Area Scoring Index (VASI) Repigmentation response in target lesions
To evaluate change in Immune Biomarkers
Trial Safety
Safety Progress
This is further along than 68% of similar trials
Side Effects for
Vehicle Cream BID
1%Tibia fracture
Trial Design
2 Treatment Groups
Ruxolitinib cream
1 of 2
Vehicle Cream
1 of 2
Experimental Treatment
Non-Treatment Group
60 Total Participants · 2 Treatment Groups
Primary Treatment: Ruxolitinib cream · Has Placebo Group · Phase 2
Ruxolitinib cream
Drug
Experimental Group · 1 Intervention: Ruxolitinib cream · Intervention Types: DrugVehicle Cream
Drug
PlaceboComparator Group · 1 Intervention: Vehicle Cream · Intervention Types: DrugTreatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Ruxolitinib
FDA approved
Trial Logistics
Trial Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 56 weeks
Who is running the clinical trial?
Incyte CorporationLead Sponsor
315 Previous Clinical Trials
46,515 Total Patients Enrolled
6 Trials studying Vitiligo
1,515 Patients Enrolled for Vitiligo
Eligibility Criteria
Age 18+ · All Participants · 3 Total Inclusion Criteria
Mark “Yes” if the following statements are true for you:At least one lesion on the skin that is indicative of vitiligo is required in order to conduct a skin biopsy
The person has nonsegmental vitiligo, meaning that they have areas of skin that have lost their pigment
We ask that you discontinue all treatments used to treat vitiligo, including screening and final safety follow-up visits
Who else is applying?
What state do they live in?
| New York | 20.0% |
| Virginia | 20.0% |
| Ontario | 10.0% |
| Other | 50.0% |
How old are they?
| 18 - 65 | 77.8% |
| 65+ | 22.2% |
What site did they apply to?
| First Oc Dermatology | 25.0% |
| UC Irvine | 25.0% |
| George Washington Medical Faculty Associates | 25.0% |
| Other | 25.0% |
What portion of applicants met pre-screening criteria?
| Did not meet criteria | 30.0% |
| Met criteria | 70.0% |
Why did patients apply to this trial?
- "I am an international medical graduate (IMG) recently migrated to USA from Ethiopia due to current political instability. its been my deepest passion participating on study specially my passion diverted toward dermatology and specifically toward vitiligo. i started to see small with patch on my skin while i was on my second year of med school and which symmetrically started to spread on my body and which honestly created unexplainable mental depression to me as young medical student. people started bulling at me and was very traumatizing moment. after coming to USA currently i joined postgraduation program on clinical research at Harvard medical school, which i believe will help me to boost my passion on research and will give good basic background. at mean time when i see this research trial, i didn't even take time to think more about it. i just started submitting the application form to see whether i am eligible for the program or not. i am willing to be part of this trial as a vitiligo victim as a patient. if i am not eligible for this, please kindly request to be part of it, which i don't really know how but use me in any area of study, let me know if i can fit in any area as a young, energetic and enthusiastic medical doctor. i believe todays research trial will defiantly be tomorrows hope for others who also suffer from vitiligo. thank you."
How many prior treatments have patients received?
| 1 | 100.0% |
How responsive is this trial?
Most responsive sites:
- Mount Sinai Hospital: < 48 hours
Average response time
- < 2 Days
Typically responds via
| Phone Call | 100.0% |
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Treatments