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Alkylating agents
Chemotherapy for Stomach Cancer
Phase 2
Waitlist Available
Research Sponsored by Robert H. Lurie Cancer Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
No serious concurrent infections or nonmalignant medical illnesses that are uncontrolled or whose control may be jeopardized by study complications
Mediastinal or hilar lymph nodes assessed by CT or MRI scan must be at least 2 cm in diameter to be considered measurable
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights
Study Summary
This trial is studying how well giving a combination of drugs works in treating patients with stomach or esophageal cancer that has spread or returned.
Who is the study for?
This trial is for adults with measurable metastatic or recurrent stomach or esophageal cancer, not just bone metastasis. It's not suitable for those curable by chemo-radiotherapy, with brain metastases, low blood counts, liver/kidney dysfunction, uncontrolled diabetes/calcium levels/seizures/psychiatric disorders, other recent cancers (except certain skin/cervical), pregnant/nursing women, and those not using contraception.Check my eligibility
What is being tested?
The study tests the effectiveness of a combination chemotherapy regimen on patients with advanced cancer of the stomach or esophagus. This Phase II trial aims to see if combining different chemotherapy drugs can better kill tumor cells in these patients.See study design
What are the potential side effects?
Chemotherapy may cause side effects like nausea, vomiting, hair loss, fatigue, increased risk of infection due to low blood cell counts and potential damage to organs such as the heart or kidneys. Specific side effects depend on the exact drugs used.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I don't have serious infections or health issues that the study could worsen.
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My lymph nodes in the chest area are at least 2 cm big as shown by a scan.
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I am 18 years old or older.
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I am able to get out of my bed or chair and move around.
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I have never had a seizure.
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My cancer is a type that started in the stomach or where the stomach meets the esophagus.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ up to 5 years
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
Treatment Details
Find a Location
Who is running the clinical trial?
Robert H. Lurie Cancer CenterLead Sponsor
21 Previous Clinical Trials
1,797 Total Patients Enrolled
National Cancer Institute (NCI)NIH
13,654 Previous Clinical Trials
40,933,153 Total Patients Enrolled
Al B. Benson, MD, FACPStudy ChairRobert H. Lurie Cancer Center
6 Previous Clinical Trials
3,155 Total Patients Enrolled
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I am 18 years old or older.I am not taking phenytoin, phenobarbital, or any seizure prevention drugs.I am not taking prochlorperazine on the day I receive irinotecan.I am only taking medication for pain, chronic conditions, or life-threatening issues.My lymph nodes in the chest area are at least 2 cm big as shown by a scan.I am able to get out of my bed or chair and move around.I don't have serious infections or health issues that the study could worsen.I haven't had any cancer except for skin cancer or cervical pre-cancer in the last 5 years.My cancer has not spread to my brain.My condition cannot be cured with chemotherapy and radiotherapy combined.I have never had a seizure.My cancer has not spread to the bones only.I do not have Gilbert's syndrome.I do not have high calcium levels causing symptoms.My cancer is a type that started in the stomach or where the stomach meets the esophagus.
Research Study Groups:
This trial has the following groups:Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Has this therapy gained regulatory endorsement?
"The safety profile of the drug receives a rating of 2 due to this being in Phase 2 and there is limited data suggesting efficacy, but some demonstrating its security."
Answered by AI
Is the research team currently accepting volunteers to participate in this experiment?
"Clinicaltrials.gov indicates that this medical trial is not currently accepting participants, as the study was initially opened on February 1st 2000 and last updated December 18th 2013. Nevertheless, there are 891 other clinical trials actively recruiting applicants at present."
Answered by AI
How many locations across the United States are currently conducting this research endeavor?
"This clinical trial is being conducted at the University of Pennsylvania Cancer Center in Philadelphia, Indiana University Cancer Center in Indianapolis, and Vanderbilt Cancer Centre in Nashville. Additionally, four other sites are also participating in this investigation."
Answered by AI
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