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Oral Antibiotics + Monitoring for Prolonged Air Leak

N/A
Waitlist Available
Led By K. Robert Shen, MD
Research Sponsored by Mayo Clinic
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Discharge from the hospital with a chest tube and valve in place
Consultation with a thoracic surgeon
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 30 days post discharge
Awards & highlights

Study Summary

This trial is testing whether giving oral antibiotics and making phone calls to check on patients' chest tubes and valves helps them recover better than the standard of care.

Who is the study for?
This trial is for men and women over 18 who are being discharged from the hospital with a chest tube and valve in place after experiencing prolonged air leaks. They must understand the study, consent to it, and have consulted with a thoracic surgeon. People allergic to Keflex or Clindamycin, pregnant individuals, or those with conditions worsened by antibiotics (subject to physician's discretion) cannot join.Check my eligibility
What is being tested?
The study compares two approaches for patients sent home with an indwelling chest tube and valve: one group receives oral antibiotics and twice-weekly phone check-ups; the other follows standard care without routine calls but waits for patients to report when their air leak stops.See study design
What are the potential side effects?
Potential side effects may include reactions related to antibiotic use such as digestive issues, allergic responses if not previously identified as allergic to prescribed medications, and possibly exacerbation of preexisting conditions sensitive to antibiotic treatment.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I was discharged from the hospital with a chest tube and valve.
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I have consulted with a thoracic surgeon.
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I am 18 years old or older.
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I understand the study and can agree to participate.
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I am either male or female.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~30 days post discharge
This trial's timeline: 3 weeks for screening, Varies for treatment, and 30 days post discharge for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in empyema in patient's discharging with an indwelling chest tube and valve.
Secondary outcome measures
Change of 30-day readmission in patient's discharging with an indwelling chest tube and valve.

Trial Design

2Treatment groups
Active Control
Group I: Group 1Active Control1 Intervention
Oral Antibiotics
Group II: Group 2Active Control1 Intervention
Standard of Care

Find a Location

Who is running the clinical trial?

Mayo ClinicLead Sponsor
3,176 Previous Clinical Trials
3,757,491 Total Patients Enrolled
K. Robert Shen, MDPrincipal InvestigatorMayo Clinic

Media Library

Standard of Care Clinical Trial Eligibility Overview. Trial Name: NCT03943511 — N/A
Prolonged Air Leak Research Study Groups: Group 1, Group 2
Prolonged Air Leak Clinical Trial 2023: Standard of Care Highlights & Side Effects. Trial Name: NCT03943511 — N/A
Standard of Care 2023 Treatment Timeline for Medical Study. Trial Name: NCT03943511 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is enlistment available for this clinical trial at the present time?

"Clinicaltrials.gov indicates that this particular trial, which was originally posted on October 7th 2019 and last updated October 25 2022 is not presently recruiting patients. Nevertheless, there are other studies actively seeking participants at the moment."

Answered by AI
~136 spots leftby Sep 2025