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Vitamin

Vitamin C for Primary Graft Dysfunction

Phase 2
Waitlist Available
Led By Micah Long, MD
Research Sponsored by University of Wisconsin, Madison
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Participant is scheduled for lung transplantation
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up at post operative day 30 and post operative day 90 via chart review
Awards & highlights

Study Summary

This study is evaluating whether vitamin C may help lung transplant patients.

Eligible Conditions
  • Primary Graft Dysfunction
  • Lung Transplant Complications

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~at post operative day 30 and post operative day 90 via chart review
This trial's timeline: 3 weeks for screening, Varies for treatment, and at post operative day 30 and post operative day 90 via chart review for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Incidence and Severity of Kidney Injury POD 2
Incidence and Severity of Kidney Injury POD 3
Incidence and Severity of Kidney Injury POD 4
+3 more
Secondary outcome measures
Incidence and Severity of PGD on POD 3
Incidence of Primary Graft Dysfunction (PGD)
Participant Thiamine Levels
+19 more

Side effects data

From 2018 Phase 2 trial • 20 Patients • NCT03148236
10%
Pericarditis
100%
80%
60%
40%
20%
0%
Study treatment Arm
Vitamin C
Placebo

Trial Design

1Treatment groups
Experimental Treatment
Group I: Vitamin C ArmExperimental Treatment1 Intervention
Ascorbic Acid will be administered at a dose of 1500 mg in 100 mL of saline over 30 minutes intravenously once every 6 hours for a total of 72 hours
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Vitamin C
2017
Completed Phase 4
~18470

Find a Location

Who is running the clinical trial?

University of Wisconsin, MadisonLead Sponsor
1,189 Previous Clinical Trials
3,169,546 Total Patients Enrolled
Micah Long, MDPrincipal InvestigatorUW School of Medicine and Public Health

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Perioperative Vitamin C Lung Transplant
2023. "Perioperative Vitamin C Lung Transplant". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04505878.
~0 spots leftby Apr 2025
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