← Back to Search

Monoclonal Antibodies

Pembrolizumab for Ovarian Cancer

Phase 2
Recruiting
Led By Janice Mehnert
Research Sponsored by Rutgers, The State University of New Jersey
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 2.5 years
Awards & highlights

Study Summary

This trial looks at how effective pembrolizumab is in treating participants with cancer that has spread to other parts of the body. Monoclonal antibodies, like pembrolizumab, may prevent tumor cells from growing and spreading.

Eligible Conditions
  • Ovarian Cancer
  • BRCA1 Mutation
  • BRCA2 Mutation
  • Solid Tumors
  • Cancer
  • POLD1 Mutation
  • Gene Mutation
  • Breast Cancer

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 2.5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 2.5 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Response rate of pembrolizuab
Secondary outcome measures
Progression free survival

Side effects data

From 2024 Phase 2 trial • 57 Patients • NCT03004183
21%
Fatigue
13%
Nausea
11%
Back pain
9%
Shortness of Breath
9%
Anemia
9%
Abdominal pain
9%
Diarrhea
7%
Pneumonia
7%
Kidney Injury and/or Infection
7%
Dyspnea
7%
Weight Loss
5%
Malnutrition, Hypercalcemia and Weakness
5%
Pneumothorax
5%
Intractable pain, back pain, hip pain
5%
Activated partial thromboplastin time prolonged
4%
Pleural effusion
4%
Atrial fibrillation with rapid ventricular response
2%
Thrombocytopenia
2%
Respiratory failure
2%
Skin rash
2%
colitis
100%
80%
60%
40%
20%
0%
Study treatment Arm
Single Arm

Trial Design

1Treatment groups
Experimental Treatment
Group I: Treatment (pembrolizumab)Experimental Treatment2 Interventions
Participants receive pembrolizumab IV over 30 minutes on day 1. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity. Participants with disease progression may continue pembrolizumab for up to 1 year.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Pembrolizumab
2017
Completed Phase 2
~2010

Find a Location

Who is running the clinical trial?

National Cancer Institute (NCI)NIH
13,658 Previous Clinical Trials
40,924,449 Total Patients Enrolled
286 Trials studying Ovarian Cancer
73,766 Patients Enrolled for Ovarian Cancer
Rutgers, The State University of New JerseyLead Sponsor
429 Previous Clinical Trials
64,192 Total Patients Enrolled
6 Trials studying Ovarian Cancer
423 Patients Enrolled for Ovarian Cancer
Janice MehnertPrincipal InvestigatorRutgers Cancer Institute of New Jersey
2 Previous Clinical Trials
295 Total Patients Enrolled

Media Library

Pembrolizumab (Monoclonal Antibodies) Clinical Trial Eligibility Overview. Trial Name: NCT03428802 — Phase 2
Ovarian Cancer Research Study Groups: Treatment (pembrolizumab)
Ovarian Cancer Clinical Trial 2023: Pembrolizumab Highlights & Side Effects. Trial Name: NCT03428802 — Phase 2
Pembrolizumab (Monoclonal Antibodies) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03428802 — Phase 2

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Has the U.S. Food and Drug Administration sanctioned Pembrolizumab?

"There is some evidence attesting to the safety of Pembrolizumab, leading it to receive a score of 2. This drug has yet to be proven efficacious in clinical trials."

Answered by AI

Is this research endeavor actively seeking participants?

"Yes, clinicaltrials.gov records confirm that this trial is presently enrolling suitable applicants. It was initially published on March 8th 2018 and revised November 16th 2022. The research team requires 40 participants from 2 distinct sites."

Answered by AI

What are the typical therapeutic applications of Pembrolizumab?

"Pembrolizumab is an effective remedy for combatting cancerous neoplasms. Additionally, this medicine can be prescribed to manage advanced melanoma, microsatellite instability high levels, and chemotherapy-induced deterioration of health."

Answered by AI

What is the accepted participant quota for this medical investigation?

"Confirmed. Clinicaltrials.gov displays that the trial, which was first made available on March 8th 2018, is currently searching for participants. In total, 40 people are required to be recruited from two medical centres."

Answered by AI

Are there any other trials that have utilized Pembrolizumab for research purposes?

"Research into Pembrolizumab is currently being conducted in 961 studies, and 122 of these are classified as Phase 3. Houston, Texas serves as the epicentre for many of the trials but there are a total 35731 locations across the globe where this drug can be tested."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
Pembrolizumab in Treating Participants With Metastatic, Recurrent or Locally Advanced Cancer and Genomic Instability
Eugenia Girda, MD 2018. "Pembrolizumab in Treating Participants With Metastatic, Recurrent or Locally Advanced Cancer and Genomic Instability". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03428802.
~6 spots leftby Apr 2025
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top