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Bortezomib following nonmyeloablative allogeneic transplant for Multiple Myeloma

Phase 2
Waitlist Available
Led By Richard LeBlanc, M.D.
Research Sponsored by Maisonneuve-Rosemont Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up at 1 and 2 years after allogeneic transplantation
Awards & highlights

Study Summary

This trial is testing whether a common cancer drug called Bortezomib can help people with myeloma who are getting a stem cell transplant. Myeloma is hard to treat and often comes back after treatment, so the hope is that this might help keep it in check better.

Eligible Conditions
  • Multiple Myeloma
  • Cancer

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~at 1 and 2 years after allogeneic transplantation
This trial's timeline: 3 weeks for screening, Varies for treatment, and at 1 and 2 years after allogeneic transplantation for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Progression-free survival
Secondary outcome measures
Graft-vs-Host Disease
Cumulative incidences of chronic GVHD
Incidence of relapse
+7 more

Trial Design

1Treatment groups
Experimental Treatment
Group I: Bortezomib post-transplantationExperimental Treatment1 Intervention
Non myeloablative allogeneic transplantation followed by Bortezomib for 1 year after a Bortezomib-based induction and autologous stem cell transplantation. Bortezomib: 1,3 mg/m2 subcutaneously every 2 weeks for 26 injections.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Bortezomib D-mannitol
FDA approved

Find a Location

Who is running the clinical trial?

Maisonneuve-Rosemont HospitalLead Sponsor
99 Previous Clinical Trials
36,283 Total Patients Enrolled
Richard LeBlanc, M.D.Principal InvestigatorHôpital Maisonneuve-Rosemont, affiliated to University of Montreal

Media Library

Bortezomib following nonmyeloablative allogeneic transplant Clinical Trial Eligibility Overview. Trial Name: NCT02308280 — Phase 2
Multiple Myeloma Research Study Groups: Bortezomib post-transplantation
Multiple Myeloma Clinical Trial 2023: Bortezomib following nonmyeloablative allogeneic transplant Highlights & Side Effects. Trial Name: NCT02308280 — Phase 2
Bortezomib following nonmyeloablative allogeneic transplant 2023 Treatment Timeline for Medical Study. Trial Name: NCT02308280 — Phase 2

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many participants are being accepted into this experimental study?

"Unfortunately, this medical trial is no longer open for patient recruitment. It was initially published on November 1st 2014 and last edited on August 22nd 2022. For those seeking other trials, 813 studies concerning multiple myeloma are actively recruiting participants as well as 142 clinical trials involving Bortezomib after a nonmyeloablative allogeneic transplantation."

Answered by AI

Is this trial accepting new participants?

"Unfortunately, the clinical trial listed on clinicialtrials.gov is no longer actively seeking participants; it was initially posted during November 2014 and last updated in August 2022. However, many other trials are recruiting patients right now - 955 to be exact."

Answered by AI

Is this research endeavor open to participants over the age of two decades?

"This medical study is limited to individuals aged 18-65 years old. For those younger or older, there are 54 and 928 studies respectively that may be more appropriate for their age groups."

Answered by AI

Has the administration given their sanction to Bortezomib following nonmyeloablative allogeneic transplant?

"Bortezomib following nonmyeloablative allogeneic transplant is assumed to have a safety rating of 2 since this clinical trial is only in Phase 2, meaning there are data points that suggest it can be relatively safe but no efficacy has been established yet."

Answered by AI

Is there any opportunity to participate in this investigation?

"To be enumerated in this trial, patients must have a diagnosis of multiple myeloma as well as meet the age requirement of 18-65. At present, there are 40 places available."

Answered by AI
~4 spots leftby Apr 2025