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Kinase Inhibitor

Loncastuximab Tesirine for Follicular Lymphoma (LOTIS-6 Trial)

Phase 2
Waitlist Available
Research Sponsored by ADC Therapeutics S.A.
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up day 1 to 30 days after end of treatment, maximum time on treatment was 333 days
Awards & highlights

LOTIS-6 Trial Summary

This trial will compare the effectiveness of loncastuximab tesirine to idelalisib in people with follicular lymphoma that has returned or does not respond to treatment.

Eligible Conditions
  • Follicular Lymphoma

LOTIS-6 Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~day 1 to 30 days after end of treatment, maximum time on treatment was 333 days
This trial's timeline: 3 weeks for screening, Varies for treatment, and day 1 to 30 days after end of treatment, maximum time on treatment was 333 days for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Complete Response Rate (CRR)
Secondary outcome measures
Average Concentration of Loncastuximab Tesirine Before Infusion
Average Concentration of Loncastuximab Tesirine at the End of Infusion
Change From Baseline in Health-Related Quality of Life (HRQoL) as Measured by the EuroQol-5 Dimensions-5 Levels (EQ-5D-5L)
+11 more

LOTIS-6 Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Loncastuximab TesirineExperimental Treatment1 Intervention
Participants will be administered loncastuximab tesirine as an intravenous (IV) infusion on Day 1 of each cycle, where 1 cycle is 3 weeks. Loncastuximab tesirine will be administered at a dose of 150 μg/kg for 2 cycles, then at a dose of 75 μg/kg for subsequent cycles.
Group II: IdelalisibActive Control1 Intervention
Participants will be administered 150 mg idelalisib, orally, twice a day throughout each cycle, where 1 cycle is 4 weeks.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Loncastuximab Tesirine
2022
Completed Phase 2
~50

Find a Location

Who is running the clinical trial?

ADC Therapeutics S.A.Lead Sponsor
28 Previous Clinical Trials
2,291 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Could you elaborate on the other investigations that have been conducted regarding Loncastuximab Tesirine?

"Currently, there are 18 ongoing research projects using Loncastuximab Tesirine with 3 of them in their final Phase. The majority of the trials take place in Cleveland, Ohio yet 581 different places have registered for various studies involving Loncastuximab Tesirine."

Answered by AI

For what ailments is Loncastuximab Tesirine frequently recommended?

"Loncastuximab Tesirine is a potent medication for chronic lymphocytic leukemia and it can also be employed to combat relapsed large b-cell lymphoma, multiple lines of systemic treatment, as well as other forms of non-Hodgkin's B-Cell Lymphomas."

Answered by AI

To what degree can the utilization of Loncastuximab Tesirine be detrimental to patients?

"Leveraging our internal evaluation criteria, Power assigned a score of 2 to Loncastuximab Tesirine's safety due to the fact that this is only a Phase 2 trial and has yet to demonstrate efficacy."

Answered by AI

Is this project actively seeking participants?

"Data hosted on clinicaltrials.gov elucidates that this trial is not presently enlisting volunteers. This research project, which was initially published on November 4th 2021, has most recently been adjusted on July 26th 2022; however, 1737 alternative trials are currently enrolling patients."

Answered by AI

What is the estimated enrolment for this clinical trial?

"This research study is no longer accepting any new participants. It was created on November 4th 2021 and last modified on July 26th 2022. For those seeking other clinical trials, there are currently 1719 studies recruiting for refractory follicular lymphoma and 18 trials involving Loncastuximab Tesirine actively enrolling patients."

Answered by AI

Does this experiment represent a pioneering approach to research?

"Since 2014, Loncastuximab Tesirine has been under investigation. The initial test was sponsored by Gilead Sciences and included 50 participants. After the Phase 1 trial success of this drug in 2014, it received its Phase 2 approval. Nowadays there are 18 concurrent trials for Loncastuximab Tesirine taking place in 176 cities over 31 countries worldwide."

Answered by AI
~2 spots leftby Apr 2025