← Back to Search

ACT + Mindfulness for Chronic Pain & Opioid Use Disorder (HOPE Trial)

N/A
Recruiting
Led By Katie Witkiewitz, PhD
Research Sponsored by University of New Mexico
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Presence of chronic pain for > 6 months in duration.
Aged 18 years or older.
Timeline
Screening 3 weeks
Treatment Varies
Follow Up change from baseline through 12-week treatment period and 12-month follow-up period
Awards & highlights

HOPE Trial Summary

This trial is testing a new treatment to help people with chronic pain & OUD reduce pain & prevent relapse. 160 people are recruited and randomized to two treatments. Results will show which is more effective.

Who is the study for?
The HOPE Trial is for adults over 18 with chronic pain and Opioid Use Disorder, who are patients at participating clinics. They must be willing to follow the study's procedures, have had chronic pain for more than six months, and been on a stable dose of buprenorphine for at least one month.Check my eligibility
What is being tested?
This trial tests whether Acceptance and Commitment Therapy combined with Mindfulness Based Relapse Prevention (ACT + MBRP) is more effective than Enhanced Usual Care in reducing pain interference and preventing relapse in individuals stabilized on buprenorphine.See study design
What are the potential side effects?
Since ACT + MBRP involves therapy without medications, side effects may include emotional discomfort or distress due to discussing personal issues but typically do not involve physical side effects.

HOPE Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I have been experiencing chronic pain for more than 6 months.
Select...
I am 18 years old or older.
Select...
I have been experiencing chronic pain for more than 6 months.
Select...
I am willing and able to follow all study rules and attend all appointments.
Select...
I am 18 years old or older.
Select...
I have been on a stable dose of buprenorphine for at least 1 month.

HOPE Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~change from baseline through 12-week treatment period and 12-month follow-up period
This trial's timeline: 3 weeks for screening, Varies for treatment, and change from baseline through 12-week treatment period and 12-month follow-up period for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Pain
Secondary outcome measures
Change in Craving
Change in Depression
Change in Pain Acceptance
+3 more

HOPE Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: ACT + MBRP InterventionExperimental Treatment1 Intervention
The ACT + MBRP group will follow a manualized clinical protocol. Treatment will include 12 weekly, virtual group-based sessions, each lasting 90 minutes. Group sizes will range from three to ten participants. All sessions will be audio recorded for fidelity. Over the course of the group meetings, participants identify areas of meaningful functioning that have been adversely impacted by pain, learn methods to enhance pain willingness in the service of these meaningful areas, and practice present-focused awareness skills. Group sessions include discussions of the impact of pain and distress avoidance, identifying alternatives to this avoidance and establishing plans for behavior change, demonstration and role-playing exercises, and homework assignments. Participants are provided with a treatment manual to help guide and inform practice outside of group sessions.
Group II: Enhanced Usual Care (EUC)Active Control1 Intervention
The Enhanced Usual Care (EUC) condition will supplement standard practices within the study sites related to chronic pain and OUD education. Participants randomized to the EUC condition will receive a brochure (in-person, via email, or via text message) with a list of chronic pain treatment resources, signs and management of opioid overdose including naloxone, and overdose prevention, and will encouraged to schedule an appointment with a clinical provider if they would like to discuss any current or past symptoms. In addition to receiving the brochure, EUC condition participants will meet with a therapist remotely for approximately 15 minutes for a descriptive overview of the brochure. In this session, the therapist will point out the resources in the brochure and read the helpful tips out loud to the participant. This session will be audio recorded for fidelity.

Find a Location

Who is running the clinical trial?

National Institute on Drug Abuse (NIDA)NIH
2,455 Previous Clinical Trials
2,596,804 Total Patients Enrolled
52 Trials studying Chronic Pain
62,262 Patients Enrolled for Chronic Pain
University of New MexicoLead Sponsor
371 Previous Clinical Trials
3,528,740 Total Patients Enrolled
7 Trials studying Chronic Pain
1,776 Patients Enrolled for Chronic Pain
University of MichiganOTHER
1,787 Previous Clinical Trials
6,365,374 Total Patients Enrolled
31 Trials studying Chronic Pain
3,646 Patients Enrolled for Chronic Pain

Media Library

Acceptance and Commitment Therapy + Mindfulness Based Relapse Prevention (ACT + MBRP) Clinical Trial Eligibility Overview. Trial Name: NCT05571917 — N/A
Chronic Pain Research Study Groups: Enhanced Usual Care (EUC), ACT + MBRP Intervention
Chronic Pain Clinical Trial 2023: Acceptance and Commitment Therapy + Mindfulness Based Relapse Prevention (ACT + MBRP) Highlights & Side Effects. Trial Name: NCT05571917 — N/A
Acceptance and Commitment Therapy + Mindfulness Based Relapse Prevention (ACT + MBRP) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05571917 — N/A
Chronic Pain Patient Testimony for trial: Trial Name: NCT05571917 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is recruitment for this experiment still active?

"Affirmative. The clinical trial is currently enrolling, with an initial posting date of 5/5/2023 and a most recent update on 5/9/2023 available via the clinicialtrials.gov website."

Answered by AI

How many individuals are partaking in this research endeavor?

"Affirmative, the information on clinicaltrials.gov infers that this medical trial is currently recruiting participants. This experiment was first posted on May 5th 2023 and most recently updated on May 9th 2023 and requires 160 patients to be sourced from two different locations."

Answered by AI

Who else is applying?

What state do they live in?
California
What site did they apply to?
University of New Mexico
What portion of applicants met pre-screening criteria?
Met criteria
How many prior treatments have patients received?
2

Why did patients apply to this trial?

I've tried all kinds of ways to try to kick this habit.
PatientReceived 2+ prior treatments

What questions have other patients asked about this trial?

Once I arrive for a screening, how long will it take for my results if I'm accepted or not?
PatientReceived 2+ prior treatments
~93 spots leftby Jun 2025