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Antisense Oligonucleotide

STP705 for Keloid

Phase 2
Waitlist Available
Led By David Goldberg, MD
Research Sponsored by Sirnaomics
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 12 months
Awards & highlights

Study Summary

This trial is testing whether a new medication can reduce the chances of a keloid (a raised scar) coming back after surgery to remove it. The trial is comparing different doses of the medication to see which is most effective with the least side effects.

Eligible Conditions
  • Keloid

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~12 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 12 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Rate of Recurrence
Secondary outcome measures
Change in DLQI score
Change in mVSS score
Change of Keloid scar appearance
+2 more

Trial Design

6Treatment groups
Experimental Treatment
Active Control
Placebo Group
Group I: Cohort 4: STP705 40 μg doseExperimental Treatment1 Intervention
STP705 at the assigned dose will be injected intradermal into the excised keloid site
Group II: Cohort 3: STP705 30 μg doseExperimental Treatment1 Intervention
STP705 at the assigned dose will be injected intradermal into the excised keloid site
Group III: Cohort 2: STP705 20 μg doseExperimental Treatment1 Intervention
STP705 at the assigned dose will be injected intradermal into the excised keloid site
Group IV: Cohort 1: STP705 10 μg doseExperimental Treatment1 Intervention
STP705 at the assigned dose will be injected intradermal into the excised keloid site
Group V: Cohort 6: SOC aloneActive Control1 Intervention
SOC (no injection)
Group VI: Cohort 5: Placebo controlPlacebo Group1 Intervention
Placebo (saline) will be injected intradermal into the excised keloid site
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
STP705
2022
Completed Phase 2
~180

Find a Location

Who is running the clinical trial?

SirnaomicsLead Sponsor
11 Previous Clinical Trials
308 Total Patients Enrolled
David Goldberg, MDPrincipal InvestigatorSchweiger Dermatology Group
3 Previous Clinical Trials
118 Total Patients Enrolled
Brenda LaTowsky, MDPrincipal InvestigatorInvestigate MD
1 Previous Clinical Trials
44 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the latest regulatory decision on STP705?

"While STP705 has yet to be proven effective, there is some data indicating that it might be safe. Our team at Power have given it a score of 2."

Answered by AI

Are people with the required medical conditions currently being signed up for this trial?

"The trial, which can be found on clinicaltrials.gov, is looking for patients that match the eligibility criteria. The listing was first put up on April 29th 2021 and was last updated on May 10th 2022."

Answered by AI

Does age limit a person's ability to participate in this research?

"According to the rules governing who can participate in this trial, individuals must be between 18-60 years old."

Answered by AI

Could I be a candidate for this particular test?

"This study is investigating keloids and thus requires patients that have this condition. Furthermore, to be eligible, individuals must be between 18-60 years old. In total, the trial will accept ~60 participants."

Answered by AI

How many people are currently signed up to participate in this research?

"That is correct, the latest information available on clinicaltrials.gov reveals that this study is still recruiting patients. This particular trial was first announced on April 29th 2021 and has been updated as recently as May 10th 2022. The investigators leading this research are hoping to enroll 60 individuals from 3 different hospitals or clinics."

Answered by AI

Who else is applying?

What site did they apply to?
Center for Clinical and Cosmetic Research
What portion of applicants met pre-screening criteria?
Did not meet criteria

Why did patients apply to this trial?

5 surgeries with reoccurrence Desperate to find a cure for keloids.
PatientReceived no prior treatments
Recent research and studies
clinicaltrials.govStudy
A Study for Safety and Efficacy Evaluation of Various Doses of STP705 in Reducing Keloid Recurrence
2021. "A Study for Safety and Efficacy Evaluation of Various Doses of STP705 in Reducing Keloid Recurrence". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04844840.
~7 spots leftby Apr 2025
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