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Local Anesthetic

Bupivicaine for Hot Flashes (R01 Trial)

Phase 2
Waitlist Available
Led By David R. Walega, MD, MSCI
Research Sponsored by Charles W Hogue
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 24 weeks (6 months) following intervention
Awards & highlights

R01 Trial Summary

This trialis testing whether a stellate ganglion block (SGB) with a local anesthetic is an effective and safe non-hormonal treatment for hot flashes and other menopausal symptoms, with the aim of improving quality of life.

Eligible Conditions
  • Hot Flashes

R01 Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 24 weeks (6 months) following intervention
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 24 weeks (6 months) following intervention for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Changes from baseline and intensity of subjective hot flashes (HF)
Secondary outcome measures
Changes from baseline of Functional MRI
Changes from baseline of Skin Sympathetic Nerve Activity (SKNA)
Changes from baseline of actigraph measures of sleep
+5 more

R01 Trial Design

2Treatment groups
Active Control
Placebo Group
Group I: BupivicaineActive Control1 Intervention
Stellate Ganglion Block injection with bupivicaine
Group II: SalinePlacebo Group1 Intervention
Saline injection

Find a Location

Who is running the clinical trial?

Charles W HogueLead Sponsor
David WalegaLead Sponsor
University of Illinois at ChicagoOTHER
608 Previous Clinical Trials
1,559,089 Total Patients Enrolled
4 Trials studying Hot Flashes
285 Patients Enrolled for Hot Flashes

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does this study accept individuals under the age of fifty?

"Based on the criteria for admission, potential participants must be between 40 and 70 years of age."

Answered by AI

What other experiments have been done to assess the efficacy of Bupivicaine?

"At present, 205 clinical trials for Bupivicaine are underway. Of these studies, 42 have advanced to Phase 3 and can be found in Germantown, Tennessee alongside 523 other sites running related experiments."

Answered by AI

Are there available spots in this trial for those seeking treatment?

"As of now, this research study is not taking on any new participants. It was first posted in July 2018 and last updated November 2022. If you are trying to find alternative trials for hot flashes or Bupivicaine, there are presently 31 and 205 studies respectively that are accepting patients."

Answered by AI

How many participants are enrolled in this experiment?

"This trial is not actively recruiting new patients; the post was first published on July 10, 2018 and last updated on November 1st 2022. However, if you are looking for alternative studies, there are 31 clinical trials searching for participants with hot flashes and 205 trials searching for those affected by Bupivicaine."

Answered by AI

Am I able to participate in this clinical experiment?

"This medical study is seeking 160 post-menopausal individuals aged 40 to 70, who experience 50 or more moderate-to-severe hot flashes per week and whose symptoms are unresponsive to approved oral treatments. A minimum of two weeks' worth of vasomotor symptom diary recording must be completed preceeding the SGB procedure (or sham treatment). Participants must also agree to fluoroscopy guidance for their procedure."

Answered by AI

What ailments is Bupivicaine typically employed to mitigate?

"Bupivicaine is a viable treatment for general surgery, lupus erythematosus cell, and ulcerative colitis."

Answered by AI

Has the Food and Drug Administration validated Bupivicaine as a viable medical treatment?

"Our team has assessed Bupivicaine's safety to be a 2, as this Phase 2 trial includes evidence of its security but not efficacy."

Answered by AI

Who else is applying?

What state do they live in?
Illinois
Iowa
How old are they?
18 - 65
What site did they apply to?
Jeewon Chon
What portion of applicants met pre-screening criteria?
Met criteria
Did not meet criteria
~24 spots leftby Apr 2025