This trial is evaluating whether long term prophylactic antibiotics will improve 1 primary outcome and 5 secondary outcomes in patients with Subarachnoid Hemorrhage. Measurement will happen over the course of EVD insertion until discharge- estimated period of time is 2 weeks.
This trial requires 150 total participants across 2 different treatment groups
This trial involves 2 different treatments. Long Term Prophylactic Antibiotics is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 1 and are in the first stage of evaluation with people.
"The total estimated rate of hemorrhage from all sources was 940 events per 10,000 person-years in the United States in 1998. In the United States, hemorrhage is thought to account for about 19 percent of all deaths." - Anonymous Online Contributor
"Heparin therapy may increase hemorrhagic complications during orthotopic liver transplantation. Patient characteristics and surgical type seem to be the best predictors of hemorrhage in this procedure." - Anonymous Online Contributor
"Hemorrhagic shock is a life-threatening condition in which significant blood loss can occur. It can lead to organ damage, and, in the severe and refractory cases, may result in blood transfusion. Bleeding is an important cause of mortality in patients admitted to a Level I trauma center." - Anonymous Online Contributor
"Results from a recent clinical trial provide additional circumstantial evidence that there are no absolute contraindications to this strategy in the setting of elective primary prophylactic antibiotic therapy for open abdominal aortic surgery." - Anonymous Online Contributor
"A simple and efficient method for closing venous puncture sites without use of suturing agents is developed. The method works well in the treatment of intra-abdominal and external hemorrhages and reduces the occurrence of complications while maintaining the effectiveness of treatment." - Anonymous Online Contributor
"Signs of traumatic hemorrhage often involve signs of shock and loss of consciousness. In less severe cases, hemorrhage may be detected through signs of a change in consciousness, blood or pleural pressures, or pulmonary changes. In severe cases, hemorrhage may be detected through signs such as anemia or abnormal coagulation tests. These signs are not necessarily limited to traumatic hemorrhage, because a change in consciousness could also be a sign of seizures or other causes of traumatic hemorrhage." - Anonymous Online Contributor
"A patient presenting with a gunshot wound, a patient with a fractured femoral neck, or a patient who has a pericardial effusion usually need operative intervention." - Anonymous Online Contributor
"These 4 cases emphasize the fact that any case can become potentially very serious and often fatal, even in the presence of an otherwise complete health plan. The first case had two of the most severe clinical manifestations seen in pediatric traumatic brain injury: 1) severe trauma-induced focal neurological impairment/death 2) a "brain dead" patient with multisystem organ disruption requiring resuscitation. The second case illustrates the need for early neurosurgical intervention in addition to other therapeutic measures. The third case illustrates the need to maintain a closed head CT at admission in adults with severe neurologic deficits." - Anonymous Online Contributor
"The current data has been accumulating since 1999. There are not sufficient results (evidence) about the superiority over other types of antibiotics. It is not possible to draw conclusions about their superiority over others." - Anonymous Online Contributor
"The average age of someone suffering a hemorrhage is 72.9. Hemorrhage is often a traumatic issue at some point in everyone's life, so it is imperative that all members of the pediatric population are aware of the signs and symptoms of bleeding. If someone notices any signs of bruising in combination with hemorrhage, they should seek medical help immediately to avoid a catastrophic outcome. The goal of medical professionals is to ensure the quickest, safest, and most favorable healing process. In a medical setting, you are likely to notice symptoms such as swelling, tenderness, a dull ache, or the tingling sensation in the extremities. Other symptoms could include sudden dizziness, extreme fatigue, low energy, and fever." - Anonymous Online Contributor
"In this population, patients with a positive family history of intracranial hemorrhage had 2.3 times the odds of having hemorrhage history compared with the general population. Patients with a positive family history of intracranial hemorrhage were 2.2 times more likely to have had a catastrophic hemorrhage, but 2.4 times less likely to have developed epilepsy. Patients with a positive family history of intracranial hemorrhage may be at increased risk for catastrophic hemorrhage and/or epilepsy." - Anonymous Online Contributor
"Long term prophylactic antibiotics can cause side effects. Some may be avoided by starting the antibiotic under a new treatment and monitoring the patient. This strategy increases the time over which the antibiotic will produce therapeutic effects, and thus, is more cost effective." - Anonymous Online Contributor