This trial is evaluating whether Imsidolimab will improve 1 primary outcome in patients with Hidradenitis Suppurativa. Measurement will happen over the course of Change in baseline in abscess and inflammatory nodule (AN) count at Week 16.
This trial requires 120 total participants across 3 different treatment groups
This trial involves 3 different treatments. Imsidolimab is the primary treatment being studied. Participants will be divided into 2 treatment groups. Some patients will receive a placebo treatment. The treatments being tested are in Phase 2 and have already been tested with other people.
"Hormonal changes, particularly those that affect skin, occur at a more gradual age in women than in men, who more frequently encounter the disorder and develop a full-blown histological pattern." - Anonymous Online Contributor
"The data from this study suggest that hidradenitis can be completely reversed with a course of antibiotic therapy over a period of 7 months with complete resolution of the clinical symptomatology." - Anonymous Online Contributor
"Skin lesions often resolve upon discontinuation of the offending agent in patients who have had hidradenitis fugax or episodic hidradenitis for less than 1 year. However, this typically happens within less than a month. A more rapid improvement in the lesions has been reported with topical corticosteroids or more intensive treatment. In these patients, patients may be diagnosed with episodic hidradenitis fugax. This rapid improvement indicates that this diagnosis is not appropriate and should be changed to episodic hidradenitis, which requires protracted treatment and results in much slower resolution over days to weeks. Most patients with hidradenitis, regardless of diagnosis, tend to have a protracted course of the disease." - Anonymous Online Contributor
"Most sufferers of hidradenitis and hidradenitis microunica will have a history of trauma to the area in the form of sharp stones entering through the anus or nose. The initial symptoms might include a sore feeling, itching, and/or irritation. As the lump develops, the symptoms will progressively worsen and the lump will begin to grow much larger - often reaching the age of 7 in children. The lump can also develop into a thick papule, but may not be painful at any stage of the growth. In severe cases the lump will grow so large that it impedes the flow of stool or blood (anemic colic)." - Anonymous Online Contributor
"This syndrome is a rare noninflammatory thyroid hormone excess due to deposition atypical colloid nodules. Patients with hidradenitis complain of the presence of nodules in both nodular and non-nodular glands of the thyroid. We describe two patients, one from Tunisia and one from Egypt, who were diagnosed with hidradenitis. We also provide a comprehensive review of the literature. Clinical features were unremarkable; physical signs and laboratory investigations were usually normal. Ultrasonography can be used for confirming the diagnosis in patients with nonpalpable nodules but its lack of specificity can lead to unnecessary thyroidectomy and consequent surgical complications." - Anonymous Online Contributor
"About 75,000 cases of hidradenitis are diagnosed each year in the United States, making it the third leading cause of chronic inflammatory skin lesions in this country." - Anonymous Online Contributor
"Since most drugs are used in several different treatment schedules, multiple medications may be needed to reduce the severity of inflammatory lesions and pain and to decrease progression to fibrosis. However, treatments appear effective in most patients with hidradenitis, and only half of patients in this series required surgical intervention. In a recent study, findings will help guide patients and providers through challenging diagnostic and treatment decisions." - Anonymous Online Contributor
"Findings from a recent study suggest that the primary cause of hidradenitis is not unilateral obstruction, but rather multifactorial defects in both upper airway physiology and lower airway clearance, specifically impaired mucociliary function." - Anonymous Online Contributor
"Immunosuppressive T1D is characterized by a high prevalence of autoimmune thyroiditis and subclinical hypothyroidism and requires a multidisciplinary approach to the diagnosis and treatment of autoimmune thyroid disease." - Anonymous Online Contributor
"In a recent study, findings suggest that C1-inhibitor inhibitor treatment might be used as a treatment for hidradenitis patients. In a recent study, findings provide the evidence for that treatment. However, clinical studies with a longer randomized controlled and larger patient number should be done." - Anonymous Online Contributor
"A significant proportion of familial hidradenitis patients have signs of ARDS. No genetic contribution to the phenotype was determined. Therefore, other factors must be involved in the genesis of familial hidradenitis." - Anonymous Online Contributor
"The vast majority of the study's patients have been in remission since immunization began, with durable response rates comparable to those reported in the clinical trials of other biologics. Treatment with Imsidolimab led to sustained improvement in most patients with IBD and/or AA associated with IFX use. Patient satisfaction with the treatment was highly favorable." - Anonymous Online Contributor