Lifestyle Cohort for Obesity, Gliosis, Weight Loss

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Obesity, Gliosis, Weight LossBehavioral Weight Loss Program - Behavioral
Eligibility
25 - 64
All Sexes
What conditions do you have?
Select

Study Summary

This trial is testing whether a weight loss intervention can improve or reverse a cellular response in the brain (gliosis) that is associated with weight regain.

Eligible Conditions
  • Obesity, Gliosis, Weight Loss

Treatment Effectiveness

Effectiveness Progress

1 of 3

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Naltrexone and Bupropion Combination
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Study Objectives

2 Primary · 0 Secondary · Reporting Duration: During 12-Month Follow-Up After Intervention

During 12-Month Follow-Up After Intervention
Weight Regain
Month 6
Weight Loss

Trial Safety

Safety Progress

1 of 3

Similar Trials

2
Naltrexone and Bupropion Combination
2
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3
Sleeve Gastrectomy Saxenda

Trial Design

3 Treatment Groups

Healthy Weight Control Cohort
1 of 3
Lifestyle Cohort
1 of 3
Surgical Cohort
1 of 3

Active Control

145 Total Participants · 3 Treatment Groups

Primary Treatment: Lifestyle Cohort · No Placebo Group · N/A

Healthy Weight Control CohortNoIntervention Group · 1 Intervention: Healthy Weight Control Cohort · Intervention Types:
Lifestyle Cohort
Behavioral
ActiveComparator Group · 1 Intervention: Behavioral Weight Loss Program · Intervention Types: Behavioral
Surgical Cohort
Procedure
ActiveComparator Group · 1 Intervention: Roux-en-Y Gastric Bypass or Sleeve Gastrectomy · Intervention Types: Procedure

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: during 12-month follow-up after intervention

Who is running the clinical trial?

University of WashingtonLead Sponsor
1,595 Previous Clinical Trials
1,568,631 Total Patients Enrolled
Ellen Schur, MD, MSPrincipal Investigator - University of Washington
Harborview Medical Center, University of Washington Medical Center
Stanford University School Of Medicine (Medical School)
University Of Wa School Of Medicine (Residency)
2 Previous Clinical Trials
146 Total Patients Enrolled

Eligibility Criteria

Age 25 - 64 · All Participants · 4 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
You have a minimum age of 25 years.
You are eligible for RYGB or Sleeve Gastrectomy and not undergoing revision or reoperation.
You are between 18.5 and 24.9 kg/m².

Who else is applying?

What state do they live in?
Washington100.0%
How old are they?
18 - 65100.0%
What site did they apply to?
University of Washington - South Lake Union100.0%
What portion of applicants met pre-screening criteria?
Met criteria100.0%
References

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