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NMDA Receptor Antagonist

Intervention Group for Depression (Ket-MDD Trial)

Phase 2
Waitlist Available
Research Sponsored by VA Connecticut Healthcare System
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline
Awards & highlights

Ket-MDD Trial Summary

Medically healthy Veterans ages 21-75 that have been diagnosed with Depression will get up to 6 treatments of Ketamine infusions, weekly. After treatment is completed, follow up will occur at 1 month, 3 months, and 6 months after completion of infusions to evaluate the longer term effects of ketamine.

Eligible Conditions
  • Depression

Ket-MDD Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in Brief Psychotic Rating Scale (BPRS)
Change in Clinician-Administered Dissociative States Scale (CADSS)
Change in Hamilton Anxiety Rating Scale (HAM-A)
+8 more

Ket-MDD Trial Design

1Treatment groups
Experimental Treatment
Group I: Intervention GroupExperimental Treatment1 Intervention
Veterans with Major Depressive Disorder getting up to 6 infusions of 0.5mg/kg ketamine in normal saline; one infusion per week, 40 minutes per infusion with time points lasting up to 5 hours.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Ketamine
FDA approved

Find a Location

Who is running the clinical trial?

VA Connecticut Healthcare SystemLead Sponsor
81 Previous Clinical Trials
6,654 Total Patients Enrolled
5 Trials studying Depression
142 Patients Enrolled for Depression

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Open Label Ketamine Treatment for Major Depressive Disorder in Veterans
Mohini Ranganathan, MD 2017. "Open Label Ketamine Treatment for Major Depressive Disorder in Veterans". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03053830.
~1 spots leftby Apr 2025
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