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Cancer Vaccine

Biological/Vaccine: Bacillus Calmette-Guerin (BCG) for Alzheimer's Disease

Phase 2
Waitlist Available
Led By Steven Arnold, MD
Research Sponsored by Steven E Arnold
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up day 364
Awards & highlights

Study Summary

This trial looks at whether the BCG vaccine could help people with Alzheimer's disease by looking at changes in cerebrospinal fluid and blood biomarkers.

Eligible Conditions
  • Alzheimer's Disease
  • Dementia
  • Mild Cognitive Impairment

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~day 364
This trial's timeline: 3 weeks for screening, Varies for treatment, and day 364 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Blood biomarkers of AD pathology-ATN
Blood biomarkers of pharmacodynamic response- cytokines
CSF biomarkers of AD pathology-ATN
+2 more

Trial Design

1Treatment groups
Experimental Treatment
Group I: BCGExperimental Treatment1 Intervention
Active BCG immunization

Find a Location

Who is running the clinical trial?

Steven E ArnoldLead Sponsor
1 Previous Clinical Trials
39 Total Patients Enrolled
Steven E Arnold, MDLead Sponsor
1 Previous Clinical Trials
39 Total Patients Enrolled
Steven Arnold, MDPrincipal InvestigatorMassachusetts General Hospital
1 Previous Clinical Trials
39 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Can people with the target ailment still participate in this research?

"Yes, this clinical trial is still recruiting patients. The latest information on the posting dates back to July 8th, 2022."

Answered by AI

How can I enroll in this research project?

"Eligible participants for this study must have a diagnosis of Alzheimer's disease, be between 55-85 years old, and not have any other major health conditions. Currently, the trial is looking to recruit 15 more patients."

Answered by AI

Can minors participate in this research trial?

"According to the eligibility criteria for this trial, the minimum age for participation is 55 and the maximum age is 85."

Answered by AI

Does the FDA recognize Bacillus Calmette-Guerin (BCG) as a safe and effective vaccine?

"While Phase 2 trials lack the data to support efficacy, there is some evidence that Biological/Vaccine: Bacillus Calmette-Guerin (BCG) is safe. Our team at Power gave it a score of 2."

Answered by AI

Who else is applying?

What state do they live in?
Arizona
Georgia
Illinois
Other
How old are they?
18 - 65
65+
What site did they apply to?
Alzheimer's Clinical and Translational Research Unit
What portion of applicants met pre-screening criteria?
Met criteria
Did not meet criteria
How many prior treatments have patients received?
1
2
0

Why did patients apply to this trial?

I am still functional but this disease continues. My husband eventually did not remember anything or anyone. I’m committed to a breakthrough. I still have years to go and there’s new breakthroughs in terms of treatment. I intend to have success in this. It was so sad to see him not remember where he lived and, eventually, who I was. I’m committed to a to new openings!!
PatientReceived no prior treatments

How responsive is this trial?

Typically responds via
Email
Recent research and studies
clinicaltrials.govStudy
A Trial to Evaluate the Effects of BCG in Adults With MCI and Mild-to-Moderate AD
Steven E Arnold, MD 2022. "A Trial to Evaluate the Effects of BCG in Adults With MCI and Mild-to-Moderate AD". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05004688.
~5 spots leftby Apr 2025
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