AZithromycin/metronidAZole Therapy for Crohn's Disease (PAZAZ Trial)

"This clinical trial is enrolling participants between the ages of 3 and 17 years old."

"Patients may enroll in this medical trial at IWK Health Centre (Halifax), North carolina Children's Hospital (Chapel Hill) and UCSF Benioff Children’s Hospital (San Francisco). Additionally, there are 5 other locations that offer enrollment for the study."

"To conduct this clinical trial, 20 qualified patients must be recruited across two locations: IWK Health Centre in Halifax and North carolina Children's Hospital in Chapel Hill."

"Affirmative. According to the clinicaltrials.gov listing, this research study is searching for volunteers and began on August 13th 2021. It was last modified April 19th 2022, with a goal of enlisting 20 patients from 5 different medical sites."

"The primary purpose of this 52-week experiment is to measure the amount of sustained remission amongst participants. Secondary goals include assessing subjects' quality of life through IMPACT III questionnaires, their Crohn's disease activity with PCDAI scores and inflammation levels via C-Reactive Protein measurements. All individuals over 9 years old will be asked to complete these tests at baseline, 12 weeks in, 24 weeks in and near the end of data collection."

"The Standard of Care was initially investigated in 2003 by the College of Medicine at University of Malawi. To date, there are 680 studies that have been completed and 103 current clinical trials recruiting patients - notably a great number located in Halifax, North carolina."

"This clinical trial is in search of 20 participants aged 3 to 17 suffering from ileocolitis. The required criteria for acceptance are as follows: a stated commitment to comply with all study protocols, signed consent forms (and assent form if applicable), mild-to-moderate disease symptoms according to PCDAI score (greater than 10 or 7.5 excluding the height item) and lower than 37.5; additionally, fecal calprotectin levels must be greater than 250 µg/g within the 30 days prior to Week 0 examination--if an endoscopy does not occur during this time period then it can take place"

"Standard of Care is applicable for individuals with genus chlamydia, adult patients and those suffering from candidal vulvovaginitis."

"Based on the available data, Standard of Care is considered safe and was given a rating of 2. This indicates that while there are some studies confirming its safety profile, no trials have confirmed any efficacy yet."