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Hormone Therapy

17Beta Estradiol, Progesterone for Cardiovascular Disease

Phase 2
Waitlist Available
Led By Chrisandra Shufelt, MD
Research Sponsored by Cedars-Sinai Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, week 6, 12, and 14 on trial
Awards & highlights

Study Summary

This trial is looking at whether low estrogen levels in young women with hypothalamic amenorrhea is associated with risk factors for cardiovascular disease.

Eligible Conditions
  • Cardiovascular Disease
  • Low Estrogen
  • Hypothalamic Amenorrhea

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, week 6, 12, and 14 on trial
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, week 6, 12, and 14 on trial for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Rate of change of peripheral arterial tonometry (PAT)
Secondary outcome measures
Anxiety
DEXA Scan
Depression
+7 more

Trial Design

2Treatment groups
Active Control
Placebo Group
Group I: 17Beta Estradiol, ProgesteroneActive Control2 Interventions
17Beta Estradiol (0.1mg/day) , Progesterone (100mg) or Medroxyprogesterone (10mg) for patient with a peanut allergy because progesterone 100mg is a peanut based product
Group II: Transdermal Placebo Patch, Placebo PillPlacebo Group2 Interventions
Placebo Transdermal Patch, Placebo Pill

Find a Location

Who is running the clinical trial?

Cedars-Sinai Medical CenterLead Sponsor
500 Previous Clinical Trials
164,870 Total Patients Enrolled
Chrisandra Shufelt, MDPrincipal Investigator - Cedars-Sinai Medical Center
Cedars-Sinai Medical Center
University Of South Carolina School Of Medicine (Medical School)
1 Previous Clinical Trials
90 Total Patients Enrolled
Noel Bairey-Merz, MDStudy DirectorCedars-Sinai Medical Center
3 Previous Clinical Trials
434 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does this trial seek seniors as participants?

"This research is seeking individuals aged 18 and above, but not exceeding 60 years old."

Answered by AI

Has research explored the effects of 17Beta Estradiol and Progesterone in conjunction with one another?

"Presently, there are 82 ongoing studies of 17Beta Estradiol, Progesterone; 16 in the concluding stage. Most such trials take place in Cheras, Kuala Lumpur but more broadly 986 medical centres across the globe are conducting similar research."

Answered by AI

Is there an opportunity for me to participate in this clinical trial?

"This clinical trial seeks thirty adults aged 18 to 60 with atherogenesis. Additionally, potential participants must be within 10% of the 1983 Metropolitan height and weight table for women's ideal bodyweight, have been diagnosed specifically with hypothalamic amenorrhea after ruling out other causes like pregnancy or thyroid dysfunction, possess a gynecological age higher than 10 years but less than 25 years old and chronologically older than eighteen."

Answered by AI

Can you speak to the potential risks of taking 17Beta Estradiol and Progesterone?

"The safety of 17Beta Estradiol, Progesterone has been assigned a value of 2 as this is only in its second phase and prior clinical studies have provided proof of it being safe but not necessarily effective."

Answered by AI

Is enrollment for this experiment still available?

"Data on clinicaltrials.gov states that this medical trial is not presently recruiting patients, despite being initially posted in January 2017 and last updated in May 2022. However, 935 other trials are actively seeking enrollees at the moment."

Answered by AI

To what conditions are 17Beta Estradiol and Progesterone typically administered?

"17Beta Estradiol and progesterone are commonly administered to treat amenorrhea, hypoestrogenism, menopausal vasomotor symptoms, and breast cancer."

Answered by AI

What is the total number of participants involved in this investigation?

"After being posted on January 1st, 2017 and last updated on May 3rd, 2022 this clinical trial has concluded its recruitment period. Fortunately, 853 other studies related to atherogenesis are still enrolling participants while 82 trials regarding 17Beta Estradiol & Progesterone remain open for those seeking a different study to join."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
Atherosclerosis, Immune Mediated Inflammation and Hypoestrogenemia in Young Women
Chrisandra Shufelt 2017. "Atherosclerosis, Immune Mediated Inflammation and Hypoestrogenemia in Young Women". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03018366.
~4 spots leftby Apr 2025
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