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Alpha-2 Adrenergic Agonist

Dexmedetomidine for Pain

Phase 3

Waitlist Available

Led By Alessia Pedoto, MD

Research Sponsored by Memorial Sloan Kettering Cancer Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Adult patients ( ≥ 21 years old) scheduled for Thoracic Surgery

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up up to 24 hours

Awards & highlights

Study Summary

This trial is testing if a drug can reduce pain for those having thoracic surgery, and if it can lower the amount of opioids needed afterwards.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ up to 24 hours

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~up to 24 hours

This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 24 hours for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Total Opioid Administered

Secondary outcome measures

Improves Analgesia

Number of Participants With Episodes of Nausea or Antiemetic Doses and/or Sedation

Side effects data

From 2020 Phase 4 trial • 798 Patients • NCT02004613

57%

Clinically important hypotension

Clinically important bradycardia

infection

stroke

Atelectasis

Hemorrhage

100%

80%

60%

40%

20%

Study treatment Arm

Placebo

Dexmedetomidine

Trial Design

2Treatment groups

Experimental Treatment

Placebo Group

Group I: DexmedetomidineExperimental Treatment1 Intervention

continuous infusion of 0.4 mcg/kg/hr

Group II: PlaceboPlacebo Group1 Intervention

continuous infusion of 0.4 mcg/kg/hr

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Dexmedetomidine

2015

Completed Phase 4

~1980

0 / 1Eligibility criteria met

Find a Location

Who is running the clinical trial?

Memorial Sloan Kettering Cancer CenterLead Sponsor

1,935 Previous Clinical Trials

588,522 Total Patients Enrolled

9 Trials studying Pain

476 Patients Enrolled for Pain

Alessia Pedoto, MDPrincipal InvestigatorMemorial Sloan Kettering Cancer Center

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any other papers that mention Dexmedetomidine?

"Currently, there are 118 ongoing clinical trials for Dexmedetomidine with 25 in Phase 3. These medical studies are situated in 222 different locations, a significant concentration of which are based in Karachi, Sindh."

Answered by AI

Could you please tell me how many other places are doing this research?

"There are 4 clinical trial sites for this medication, all of which are based in New york. The locations are: Commack, Harrison, and other cities with 4 additional locations. If you choose to participate in this study, please select the clinic nearest you to reduce travelling time and effort."

Answered by AI

What medical conditions does Dexmedetomidine typically help alleviate?

"Dexmedetomidine can be used to treat various disorders such as disease, ventilations, and cyclic vomiting syndrome."

Answered by AI

Could you please elaborate on the possible risks of Dexmedetomidine?

"Dexmedetomidine is classified as a level 3 medication, meaning that while there are efficacy data from clinical trials, this drug has undergone multiple rounds of testing to confirm its safety."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Placebo Controlled Clinical Trial of the Postoperative Opioid Sparing Effects of Intraoperative Dexmedetomidine Infusion for Thoracic Surgery

2013. "Placebo Controlled Clinical Trial of the Postoperative Opioid Sparing Effects of Intraoperative Dexmedetomidine Infusion for Thoracic Surgery". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT01973452.