Brain Imaging for Predicting Obesity Risks

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: University of Nebraska Lincoln

Disqualifiers: Metal in body, pregnancy, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 1

187 Participants Needed

What You Need to Know Before You Apply

What is the purpose of this trial?

The purpose of this study is to examine how certain factors in childhood and adolescence relate to neural vulnerabilities for obesity in young adulthood. It is hypothesized that specific individual and environmental factors will significantly predict neural vulnerabilities for obesity.

Who Is on the Research Team?

Timothy D Nelson, Ph.D.

Principal Investigator

University of Nebraska Lincoln

Are You a Good Fit for This Trial?

This trial is for adults who are at least 19 years old and have either taken part in the Preschool Problem Solving Study or lived in Lancaster County, NE during high school. If not from the study, participants must be no older than 20. Pregnant individuals, those with braces, non-removable piercings, hair extensions, or metal inside their body cannot join.

Inclusion Criteria

I am 19 years old or older.

You have either participated in the Preschool Problem Solving Study before or lived in Lancaster County, NE during some part of high school.

Exclusion Criteria

Contraindications for functional magnetic resonance imaging (fMRI): hair extensions

Contraindications for functional magnetic resonance imaging (fMRI): metal in body

I am 20 or younger and lived in Lancaster County during high school.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

fMRI Task

Participants are delivered sips of appetizing tastes (milkshake) and tasteless solution while in the MRI scanner

1 session

1 visit (in-person)

Follow-up

Participants are monitored for safety and effectiveness after the fMRI task

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

• Milkshake fMRI

Trial Overview The study is looking into how childhood and adolescent experiences influence brain responses related to obesity risk in young adulthood using an fMRI while participants taste milkshakes. It aims to identify individual and environmental factors that might predict these neural vulnerabilities.

How Is the Trial Designed?

Group I: fMRI Experimental Treatment 1 Intervention

Participants are delivered sips of appetizing tastes (milkshake) and tasteless solution throughout the task while in the MRI scanner.

Who Is Running the Clinical Trial?

University of Nebraska Lincoln

Lead Sponsor

Trials

40

Recruited

13,200+

Gretchen Swanson Center for Nutrition

Collaborator

Trials

3

Recruited

890+

University of Utah

Collaborator

Trials

1,169

Recruited

1,623,000+

Wayne State University

Collaborator

Trials

318

Recruited

111,000+

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Collaborator

Trials

2,513

Recruited

4,366,000+

University of Nebraska

Collaborator

Trials

563

Recruited

1,147,000+

The University of Texas at San Antonio

Collaborator

Trials

24

Recruited

7,600+

Stanford University

Collaborator

Trials

2,527

Recruited

17,430,000+