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Phosphodiesterase Type 5 Inhibitor

Sildenafil for Kidney Transplant

N/A

Waitlist Available

Research Sponsored by University of British Columbia

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 90 days postop

Awards & highlights

Study Summary

This trial looks at whether a drug that increases blood flow can reduce damage to kidneys during transplant surgery.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 90 days postop

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~90 days postop

This trial's timeline: 3 weeks for screening, Varies for treatment, and 90 days postop for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

renal transplant function within 90 days postop

Secondary outcome measures

perioperative safety of sildenafil administration in renal transplantation

Side effects data

From 2018 Phase 4 trial • 6 Patients • NCT01642407

50%

Bronchitis

50%

Nasopharyngitis

50%

Upper respiratory tract infection

33%

Headache

33%

Epistaxis

33%

Diarrhoea

33%

Gastroenteritis

17%

Vision blurred

17%

Eczema

17%

Rash

17%

Flushing

17%

Alanine aminotransferase increased

17%

Ammonia increased

17%

Aspartate aminotransferase increased

17%

Weight increased

17%

Dysmenorrhoea

17%

Erection increased

17%

Pulmonary arterial hypertension

17%

Rhinitis allergic

17%

Acne

17%

Dermatitis diaper

17%

Dry skin

17%

Visual acuity reduced transiently

17%

Colitis

17%

Molluscum contagiosum

17%

Streptococcal infection

17%

Blood urine present

17%

Myalgia

17%

Cardiac failure

17%

Conjunctivitis allergic

17%

Dental caries

17%

Vomiting

17%

Chest pain

17%

Feeling abnormal

17%

Influenza

100%

80%

60%

40%

20%

Study treatment Arm

Sildenafil

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: interventionExperimental Treatment1 Intervention

sildenafil administration perioperative to renal transplant

Group II: controlActive Control1 Intervention

renal transplant recipients

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Sildenafil

FDA approved

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

University of British ColumbiaLead Sponsor

1,415 Previous Clinical Trials

2,466,916 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What indications are usually seen to justify the use of Sildenafil?

"Sildenafil is a potent therapeutic option for circumstances such as premature ejaculation, the advancement of NYHA functional class II-III pulmonary arterial hypertension, and other varieties of pulmonary arterial hypertension."

Answered by AI

Are any new individuals being enrolled into this experiment at the moment?

"As of now, this medical trial is not actively recruiting any participants. It was initially posted on April 1st 2021 and most recently updated on November 3rd 2020. If you are interested in being enrolled into a study, there are presently two trials involving kidney disease that have openings as well as 23 Sildenafil-related investigations requiring volunteers."

Answered by AI

What is the enrollment quota for this scientific experiment?

"This clinical trial is no longer open for enrollment. The study was posted on April 1st 2021 and final changes were made on November 3rd 2020. For individuals interested in other trials, there are currently two kidney-focused studies as well as 23 Sildenafil-related investigations actively recruiting participants."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

PDE5i Use in Renal Transplant Recipients

Christopher Nguan 2021. "PDE5i Use in Renal Transplant Recipients". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04122105.

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