Computerized Cognitive Rehabilitation for ICU Survivorship
(RETURN-III Trial)
Trial Summary
Do I need to stop my current medications for this trial?
The trial protocol does not specify whether you need to stop taking your current medications.
What data supports the effectiveness of the treatment Computerized Cognitive Rehabilitation for ICU Survivorship?
Research shows that early cognitive rehabilitation training can significantly improve planning, decision-making, and executive function in ICU patients with cognitive impairment. Additionally, early rehabilitation in the ICU may reduce complications associated with post-intensive care syndrome, which includes cognitive impairments.12345
Is computerized cognitive rehabilitation safe for humans?
How is Computerized Cognitive Rehabilitation different from other treatments for ICU survivorship?
Computerized Cognitive Rehabilitation is unique because it uses computer programs to help improve cognitive functions like memory and attention, offering a flexible and individualized approach compared to traditional methods like pen and paper exercises. This treatment is particularly novel as it allows for personalized therapy that can be adjusted to the specific needs of each patient, potentially enhancing recovery outcomes.910111213
What is the purpose of this trial?
Millions of patients survive care in medical and surgical Intensive Care Units (ICUs) every year, only to suffer from a new or accelerated dementia-like process, called post-ICU long-term cognitive impairment (ICU-LTCI). ICU-LTCI causes considerable problems with personal relationships, return to work, and everyday tasks, such as managing medicines and money. No treatment for these patients is currently available. Technology using computerized cognitive rehabilitation could improve ICU-LTCI by harnessing the healing potential of the brain (i.e., neuroplasticity). This intervention is scalable, portable, and economical. The investigators will evaluate the effectiveness of computerized cognitive rehabilitation in a randomized controlled trial of 160 VA patients with ICU-LTCI. The investigators hypothesize that this intervention could improve cognition, and brain structure shown by MRI. This research has high potential to influence rehabilitation strategies for Veteran and civilian ICU survivors.
Research Team
E. Wesley Ely, MD MPH
Principal Investigator
Tennessee Valley Healthcare System Nashville Campus, Nashville, TN
Mayur B Patel, MD MPH
Principal Investigator
Tennessee Valley Healthcare System Nashville Campus, Nashville, TN
Eligibility Criteria
This trial is for adults who've recently been in an ICU due to respiratory failure or shock, are now stable, and live close enough to the study site. It's not for those with severe pre-existing cognitive issues, substance abuse problems that prevent independent living, active suicidal thoughts, or sensory impairments that hinder communication.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive Computerized Cognitive Rehabilitation or active control computer games
Follow-up
Participants are monitored for cognitive improvements and safety post-treatment
Treatment Details
Interventions
- Computerized Cognitive Rehabilitation
Find a Clinic Near You
Who Is Running the Clinical Trial?
VA Office of Research and Development
Lead Sponsor
Vanderbilt University Medical Center
Collaborator